Premeal insulin lispro plus bedtime NPH or twice-daily NPH in patients with type 2 diabetes: acute postprandial and chronic effects on glycemic control and cardiovascular risk factors

Antonio Ceriello, Stefano Del Prato, Juliana Bue-Valleskey, Scott Beattie, Jeffrey Gates, Amparo de la Peña, James Malone

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Two insulin regimens were used to explore acute and chronic postprandial changes in glycemia, lipemia, and metabolic markers associated with increased risk of cardiovascular disease. Methods: An open-label, randomized, two-period crossover study (12 weeks/period) compared a prandial regimen [premeal insulin lispro + bedtime neutral protamine Hagedorn (NPH)] with a basal regimen (twice-daily NPH). There were 30 patients (12 women and 18 men; mean age=61 years) with type 2 diabetes mellitus (mean duration=16 years) who were randomized after a 2-month lead-in with twice-daily NPH treatment. A standard lunch test meal developed according to each patient's caloric needs was administered at the end of each treatment period. Results: Insulin lispro was associated with significantly lower postprandial glucose (area under the curve0-5 h=43.54 vs. 57.65 mM/h; P1c (HbA1c; mean±SE=7.6±0.2 vs. 8.2±0.2%; P1c and acute modulation of lipid fractions after a test meal. These biochemical modifications may potentially have a favorable impact on cardiovascular risk in patients with type 2 diabetes mellitus.

Original languageEnglish
Pages (from-to)20-27
Number of pages8
JournalJournal of Diabetes and its Complications
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 2007

Keywords

  • Diabetes
  • Lispro
  • NPH
  • Postprandial
  • Test meal

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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