Premenopausal Circulating Androgens and Risk of Endometrial Cancer

results of a Prospective Study

Tess V. Clendenen, Kathryn Hertzmark, Karen L. Koenig, Eva Lundin, Sabina Rinaldi, Theron Johnson, Vittorio Krogh, Göran Hallmans, Annika Idahl, Annekatrin Lukanova, Anne Zeleniuch-Jacquotte

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Endometrial cancer risk is increased by estrogens unopposed by progesterone. In premenopausal women, androgen excess is often associated with progesterone insufficiency, suggesting that premenopausal androgen concentrations may be associated with risk. In a case–control study nested within three cohorts, we assessed the relationship between premenopausal androgens and risk of endometrial cancer (161 cases and 303 controls matched on age and date of blood donation). Testosterone, DHEAS, androstenedione, and SHBG were measured in serum or plasma. Free testosterone was calculated from testosterone and SHBG. We observed trends of increasing risk across tertiles of testosterone (ORT3-T1 = 1.59, 95 % CI = 0.96, 2.64, p = 0.08) and free testosterone (ORT3-T1 = 1.76, 95 % CI = 1.01, 3.07, p = 0.047), which were not statistically significant after adjustment for body mass index (BMI). There was no association for DHEAS, androstenedione, or SHBG. There were significant interactions by age at diagnosis (

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalHormones and Cancer
DOIs
Publication statusAccepted/In press - Feb 29 2016

Fingerprint

Endometrial Neoplasms
Androgens
Testosterone
Prospective Studies
Androstenedione
Progesterone
Blood Donors
Estrogens
Body Mass Index
Serum

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Endocrine and Autonomic Systems

Cite this

Clendenen, T. V., Hertzmark, K., Koenig, K. L., Lundin, E., Rinaldi, S., Johnson, T., ... Zeleniuch-Jacquotte, A. (Accepted/In press). Premenopausal Circulating Androgens and Risk of Endometrial Cancer: results of a Prospective Study. Hormones and Cancer, 1-10. https://doi.org/10.1007/s12672-016-0258-1

Premenopausal Circulating Androgens and Risk of Endometrial Cancer : results of a Prospective Study. / Clendenen, Tess V.; Hertzmark, Kathryn; Koenig, Karen L.; Lundin, Eva; Rinaldi, Sabina; Johnson, Theron; Krogh, Vittorio; Hallmans, Göran; Idahl, Annika; Lukanova, Annekatrin; Zeleniuch-Jacquotte, Anne.

In: Hormones and Cancer, 29.02.2016, p. 1-10.

Research output: Contribution to journalArticle

Clendenen, TV, Hertzmark, K, Koenig, KL, Lundin, E, Rinaldi, S, Johnson, T, Krogh, V, Hallmans, G, Idahl, A, Lukanova, A & Zeleniuch-Jacquotte, A 2016, 'Premenopausal Circulating Androgens and Risk of Endometrial Cancer: results of a Prospective Study', Hormones and Cancer, pp. 1-10. https://doi.org/10.1007/s12672-016-0258-1
Clendenen, Tess V. ; Hertzmark, Kathryn ; Koenig, Karen L. ; Lundin, Eva ; Rinaldi, Sabina ; Johnson, Theron ; Krogh, Vittorio ; Hallmans, Göran ; Idahl, Annika ; Lukanova, Annekatrin ; Zeleniuch-Jacquotte, Anne. / Premenopausal Circulating Androgens and Risk of Endometrial Cancer : results of a Prospective Study. In: Hormones and Cancer. 2016 ; pp. 1-10.
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