Prenatal diagnosis of congenital human cytomegalovirus infection

U. Nicolini, A. Kustermann, B. Tassis, R. Fogliani, A. Galimberti, E. Percivalle, M. G. Revello, G. Gerna

Research output: Contribution to journalArticle

Abstract

Fifteen fetuses at risk of congenital human cytomegalovirus (HCMV) infection underwent prenatal diagnosis at 16-30 weeks' gestation by a combination of amniocentesis and fetal blood sampling. HCMV was isolated from the amniotic fluid in six patients, but HCMV-specific IgM was detected in only three of them. Two of the nine neonates, who were delivered following a negative prenatal diagnosis, had congenital HCMV infection diagnosed by virus isolation in the urine. The interval from infection to prenatal testing was 3 and 4 weeks in the two false-negative cases and ≥7 weeks in the true-positive cases. Although timely testing for HCMV infection allows the option of termination of pregnancy, it may be flawed by false-negative results.

Original languageEnglish
Pages (from-to)903-906
Number of pages4
JournalPrenatal Diagnosis
Volume14
Issue number10
DOIs
Publication statusPublished - 1994

Fingerprint

Cytomegalovirus Infections
Prenatal Diagnosis
Cytomegalovirus
Pregnancy
Amniocentesis
Amniotic Fluid
Fetal Blood
Immunoglobulin M
Fetus
Urine
Newborn Infant
Viruses
Infection

Keywords

  • Congenital human cytomegalovirus infection
  • Prenatal diagnosis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynaecology

Cite this

Prenatal diagnosis of congenital human cytomegalovirus infection. / Nicolini, U.; Kustermann, A.; Tassis, B.; Fogliani, R.; Galimberti, A.; Percivalle, E.; Revello, M. G.; Gerna, G.

In: Prenatal Diagnosis, Vol. 14, No. 10, 1994, p. 903-906.

Research output: Contribution to journalArticle

Nicolini, U. ; Kustermann, A. ; Tassis, B. ; Fogliani, R. ; Galimberti, A. ; Percivalle, E. ; Revello, M. G. ; Gerna, G. / Prenatal diagnosis of congenital human cytomegalovirus infection. In: Prenatal Diagnosis. 1994 ; Vol. 14, No. 10. pp. 903-906.
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