Prenatal diagnosis of congenital human cytomegalovirus infection

U. Nicolini, A. Kustermann, B. Tassis, R. Fogliani, A. Galimberti, E. Percivalle, M. G. Revello, G. Gerna

Research output: Contribution to journalArticlepeer-review


Fifteen fetuses at risk of congenital human cytomegalovirus (HCMV) infection underwent prenatal diagnosis at 16-30 weeks' gestation by a combination of amniocentesis and fetal blood sampling. HCMV was isolated from the amniotic fluid in six patients, but HCMV-specific IgM was detected in only three of them. Two of the nine neonates, who were delivered following a negative prenatal diagnosis, had congenital HCMV infection diagnosed by virus isolation in the urine. The interval from infection to prenatal testing was 3 and 4 weeks in the two false-negative cases and ≥7 weeks in the true-positive cases. Although timely testing for HCMV infection allows the option of termination of pregnancy, it may be flawed by false-negative results.

Original languageEnglish
Pages (from-to)903-906
Number of pages4
JournalPrenatal Diagnosis
Issue number10
Publication statusPublished - 1994


  • Congenital human cytomegalovirus infection
  • Prenatal diagnosis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynaecology


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