Prenatal diagnosis of metabolic diseases on chorionic villi obtained before the ninth week of pregnancy

A. Minelli, M. Piantanida, G. Simoni, F. Rossella, L. Romitti, B. Brambati, C. Danesino

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Nine pregnancies at risk for various metabolic disorders were monitored by prenatal diagnosis on chorionic villi obtained between the sixth and ninth weeks of pregnancy. A diagnosis of an affected fetus was made in five cases (Sandhoff, Tay-Sachs (2), Pompe's, GM1), while metachromatic leukodystrophy, GM1 (2), and Pompe's were excluded in four cases. It is concluded that chorionic villi are a reliable tissue for prenatal diagnosis of metabolic disorders also when obtained before the ninth week.

Original languageEnglish
Pages (from-to)959-963
Number of pages5
JournalPrenatal Diagnosis
Issue number11
Publication statusPublished - 1992


ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynaecology

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