Prenatal exposure to methylazoxymethanol acetate in the rat alters neurotrophin levels and behavior: Considerations for neurodevelopmental diseases

Marco Fiore, Jakob Korf, Francesco Angelucci, Lucia Talamini, Luigi Aloe

Research output: Contribution to journalArticle

Abstract

We did a single injection of methylazoxymethanol acetate (MAM) in pregnant rats on gestational day (GD) 11 or 12 to investigate the long-lasting effects of early entorhinal cortex (EC) and hippocampus maldevelopment on behavior, brain nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels, and the neurotrophin receptor p75 and choline acetyltransferase (ChAT) immunoreactivity. Adult animals treated with MAM had compromised EC development and showed changes in locomotion and displacement activities. In addition, rats treated on GD 12 had increased concentration of NGF and BDNF in the EC and hippocampus if compared to control rats. Prenatal MAM administration did not affect significantly p75 and ChAT distribution in the EC and septum. Results are discussed in reference to the neurodevelopmental hypothesis of psychiatric disorders.

Original languageEnglish
Pages (from-to)57-67
Number of pages11
JournalPhysiology and Behavior
Volume71
Issue number1-2
DOIs
Publication statusPublished - 2000

Keywords

  • BDNF
  • Behavior
  • ChAT
  • NGF
  • p75
  • Schizophrenia

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Prenatal exposure to methylazoxymethanol acetate in the rat alters neurotrophin levels and behavior: Considerations for neurodevelopmental diseases'. Together they form a unique fingerprint.

  • Cite this