Abstract
We did a single injection of methylazoxymethanol acetate (MAM) in pregnant rats on gestational day (GD) 11 or 12 to investigate the long-lasting effects of early entorhinal cortex (EC) and hippocampus maldevelopment on behavior, brain nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels, and the neurotrophin receptor p75 and choline acetyltransferase (ChAT) immunoreactivity. Adult animals treated with MAM had compromised EC development and showed changes in locomotion and displacement activities. In addition, rats treated on GD 12 had increased concentration of NGF and BDNF in the EC and hippocampus if compared to control rats. Prenatal MAM administration did not affect significantly p75 and ChAT distribution in the EC and septum. Results are discussed in reference to the neurodevelopmental hypothesis of psychiatric disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 57-67 |
| Number of pages | 11 |
| Journal | Physiology and Behavior |
| Volume | 71 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2000 |
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Keywords
- BDNF
- Behavior
- ChAT
- NGF
- p75
- Schizophrenia
ASJC Scopus subject areas
- Behavioral Neuroscience
- Physiology (medical)
Cite this
Prenatal exposure to methylazoxymethanol acetate in the rat alters neurotrophin levels and behavior : Considerations for neurodevelopmental diseases. / Fiore, Marco; Korf, Jakob; Angelucci, Francesco; Talamini, Lucia; Aloe, Luigi.
In: Physiology and Behavior, Vol. 71, No. 1-2, 2000, p. 57-67.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prenatal exposure to methylazoxymethanol acetate in the rat alters neurotrophin levels and behavior
T2 - Considerations for neurodevelopmental diseases
AU - Fiore, Marco
AU - Korf, Jakob
AU - Angelucci, Francesco
AU - Talamini, Lucia
AU - Aloe, Luigi
PY - 2000
Y1 - 2000
N2 - We did a single injection of methylazoxymethanol acetate (MAM) in pregnant rats on gestational day (GD) 11 or 12 to investigate the long-lasting effects of early entorhinal cortex (EC) and hippocampus maldevelopment on behavior, brain nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels, and the neurotrophin receptor p75 and choline acetyltransferase (ChAT) immunoreactivity. Adult animals treated with MAM had compromised EC development and showed changes in locomotion and displacement activities. In addition, rats treated on GD 12 had increased concentration of NGF and BDNF in the EC and hippocampus if compared to control rats. Prenatal MAM administration did not affect significantly p75 and ChAT distribution in the EC and septum. Results are discussed in reference to the neurodevelopmental hypothesis of psychiatric disorders.
AB - We did a single injection of methylazoxymethanol acetate (MAM) in pregnant rats on gestational day (GD) 11 or 12 to investigate the long-lasting effects of early entorhinal cortex (EC) and hippocampus maldevelopment on behavior, brain nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels, and the neurotrophin receptor p75 and choline acetyltransferase (ChAT) immunoreactivity. Adult animals treated with MAM had compromised EC development and showed changes in locomotion and displacement activities. In addition, rats treated on GD 12 had increased concentration of NGF and BDNF in the EC and hippocampus if compared to control rats. Prenatal MAM administration did not affect significantly p75 and ChAT distribution in the EC and septum. Results are discussed in reference to the neurodevelopmental hypothesis of psychiatric disorders.
KW - BDNF
KW - Behavior
KW - ChAT
KW - NGF
KW - p75
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=0034530545&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034530545&partnerID=8YFLogxK
U2 - 10.1016/S0031-9384(00)00310-3
DO - 10.1016/S0031-9384(00)00310-3
M3 - Article
C2 - 11134686
AN - SCOPUS:0034530545
VL - 71
SP - 57
EP - 67
JO - Physiology and Behavior
JF - Physiology and Behavior
SN - 0031-9384
IS - 1-2
ER -