Prenatal imaging features and postnatal outcomes of isolated fetal duplex renal collecting system: A systematic review and meta-analysis

Francesca Bascietto, Asma Khalil, Giuseppe Rizzo, Alexander Makatsariya, Danilo Buca, Claudia Silvi, Matteo Ucci, Marco Liberati, Alessandra Familiari, Francesco D'Antonio

Research output: Contribution to journalReview article

Abstract

Objectives: To perform a systematic review of studies reporting the outcome of fetuses with a prenatal diagnosis of isolated duplex collecting system (DCS). Methods: Inclusion criteria were studies reporting the outcome of fetuses with a prenatal diagnosis of isolated DCS, defined as DCS not associated with other major structural anomalies at the time of diagnosis. The outcomes observed were: imaging features of DCS on prenatal ultrasound, associated anomalies detected exclusively at prenatal follow-up ultrasound and at birth, abnormal karyotype, symptoms at birth (including vesicoureteral reflux [VUR] and urinary tract infections [UTI]), need for and type of surgical approach, complications after surgery, and accuracy of prenatal ultrasound in correctly identifying this anomaly. Results: Eleven studies (284 fetuses with a prenatal diagnosis of DCS) were included. On ultrasound, DCS was associated with ureterocele in 70.7% and with megaureter in 36.6% of cases. Worsening of pelvic/ureteric dilatation was reported to occur in 41.3% of fetuses. At birth, 4.3% of fetuses affected by DCS showed associated renal anomalies. After birth, VUR and UTI presented in 51.3% and 21.7% of children respectively, while 33.6% required surgery. Prenatal diagnosis of DCS was confirmed in 90.9% of included cases. Conclusion: DCS diagnosed prenatally is associated with a generally good outcome. Prenatal ultrasound has a good diagnostic accuracy, while detailed postnatal assessment is required in order to identify associated renal anomalies.

Original languageEnglish
Pages (from-to)424-431
Number of pages8
JournalPrenatal Diagnosis
Volume40
Issue number4
DOIs
Publication statusPublished - Mar 1 2020

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Genetics(clinical)

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    Bascietto, F., Khalil, A., Rizzo, G., Makatsariya, A., Buca, D., Silvi, C., Ucci, M., Liberati, M., Familiari, A., & D'Antonio, F. (2020). Prenatal imaging features and postnatal outcomes of isolated fetal duplex renal collecting system: A systematic review and meta-analysis. Prenatal Diagnosis, 40(4), 424-431. https://doi.org/10.1002/pd.5622