Prenatal treatment of congenital human cytomegalovirus infection by fetal intravascular administration of ganciclovir

M. Gracia Revello, Elena Percivalle, Fausto Baldanti, Giuseppe Gerna, Alessandra Kustermann, Simona Nava, Umberto Nicolini

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Ganciclovir was administered 'in utero' for 12 days in a 29-week-old fetus with ascertained congenital human cytomegalovirus (HCMV) infection, thrombocytopenia and elevated γ-glutamyl transferase (γGT) value. Efficacy of therapy was shown by reduction in virus titer of amniotic fluid and fetal urine, disappearance of viral DNA in fetal blood, and normalization of platelet count and γGT value. However, stillbirth occurred at 32 weeks of gestation and HCMV inclusion bodies were detected in kidneys, lungs, heart and pancreas at autopsy. During therapy, side-effects,possibly related to ganciclovir administration, were observed.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalClinical and Diagnostic Virology
Volume1
Issue number1
DOIs
Publication statusPublished - 1993

Fingerprint

Ganciclovir
Cytomegalovirus Infections
Transferases
Stillbirth
Inclusion Bodies
Viral DNA
Amniotic Fluid
Viral Load
Cytomegalovirus
Platelet Count
Fetal Blood
Thrombocytopenia
Pancreas
Autopsy
Fetus
Urine
Kidney
Pregnancy
Lung
Therapeutics

Keywords

  • Ganciclovir
  • Human cytomegalovirus
  • Prenatal diagnosis
  • Prenatal treatment

ASJC Scopus subject areas

  • Virology

Cite this

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abstract = "Ganciclovir was administered 'in utero' for 12 days in a 29-week-old fetus with ascertained congenital human cytomegalovirus (HCMV) infection, thrombocytopenia and elevated γ-glutamyl transferase (γGT) value. Efficacy of therapy was shown by reduction in virus titer of amniotic fluid and fetal urine, disappearance of viral DNA in fetal blood, and normalization of platelet count and γGT value. However, stillbirth occurred at 32 weeks of gestation and HCMV inclusion bodies were detected in kidneys, lungs, heart and pancreas at autopsy. During therapy, side-effects,possibly related to ganciclovir administration, were observed.",
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AU - Gracia Revello, M.

AU - Percivalle, Elena

AU - Baldanti, Fausto

AU - Gerna, Giuseppe

AU - Kustermann, Alessandra

AU - Nava, Simona

AU - Nicolini, Umberto

PY - 1993

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