TY - JOUR
T1 - Prenatal ultrasound factors and genetic disorders in pregnancies complicated by polyhydramnios
AU - Boito, Simona
AU - Crovetto, Francesca
AU - Ischia, Benedetta
AU - Crippa, Beatrice Letizia
AU - Fabietti, Isabella
AU - Bedeschi, Maria Francesca
AU - Lalatta, Faustina
AU - Colombo, Lorenzo
AU - Mosca, Fabio
AU - Fedele, Luigi
AU - Persico, Nicola
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Objective: The objective of the study is to examine the incidence of chromosomal or genetic abnormalities in pregnancies complicated by polyhydramnios and to assess the value of prenatal ultrasound findings in the prediction of cases associated with such disorders. Methods: We searched the prenatal records of all patients delivered in our hospital with a diagnosis of polyhydramnios during pregnancy. For each case, maternal characteristics, ultrasound findings, and genetic testing results were recorded. A postnatal follow-up program of at least 6 months, including a clinical assessment by a clinical geneticist, was carried out in all cases. Results: On a total of 195 cases, genetic testing and clinical examination identified a chromosomal or genetic disease in 26 (13.3%) cases. Multivariate analysis demonstrated that significant predictors of a genetic disorder were a deepest vertical pocket of amniotic fluid of ≥13.0 cm (OR 4.306, 95%CI: 1.535–12.079) and reduced fetal movements (OR 25.084, 95%CI: 4.577–137.461), but not the presence of a structural defect. Conclusion: A postnatal clinical follow-up program can reveal chromosomal or genetic disorders in about 13% of neonates with a prenatal diagnosis of polyhydramnios. The severity of polyhydramnios and the reduction of fetal movements are independently associated with the presence of such diseases.
AB - Objective: The objective of the study is to examine the incidence of chromosomal or genetic abnormalities in pregnancies complicated by polyhydramnios and to assess the value of prenatal ultrasound findings in the prediction of cases associated with such disorders. Methods: We searched the prenatal records of all patients delivered in our hospital with a diagnosis of polyhydramnios during pregnancy. For each case, maternal characteristics, ultrasound findings, and genetic testing results were recorded. A postnatal follow-up program of at least 6 months, including a clinical assessment by a clinical geneticist, was carried out in all cases. Results: On a total of 195 cases, genetic testing and clinical examination identified a chromosomal or genetic disease in 26 (13.3%) cases. Multivariate analysis demonstrated that significant predictors of a genetic disorder were a deepest vertical pocket of amniotic fluid of ≥13.0 cm (OR 4.306, 95%CI: 1.535–12.079) and reduced fetal movements (OR 25.084, 95%CI: 4.577–137.461), but not the presence of a structural defect. Conclusion: A postnatal clinical follow-up program can reveal chromosomal or genetic disorders in about 13% of neonates with a prenatal diagnosis of polyhydramnios. The severity of polyhydramnios and the reduction of fetal movements are independently associated with the presence of such diseases.
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U2 - 10.1002/pd.4851
DO - 10.1002/pd.4851
M3 - Article
C2 - 27247190
AN - SCOPUS:84981240778
VL - 36
SP - 726
EP - 730
JO - Prenatal Diagnosis
JF - Prenatal Diagnosis
SN - 0197-3851
IS - 8
ER -