Prenatal vitamin supplementation and risk of childhood brain tumors

S. Preston-Martin, J. M. Pogoda, B. A. Mueller, F. Lubin, E. A. Holly, G. Filippini, S. Cordier, R. Peris-Bonet, W. Choi, J. Little, A. Arslan

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Abstract

An international case-control study of primary pediatric brain tumors included interviews with mothers of cases diagnosed from 1976 to 1994 and mothers of population controls. Data are available on maternal vitamin use during pregnancy for 1,051 cases and for 1,919 controls from 8 geographic areas in North America, Europe and Israel. While risk estimates varied by study center, combined results suggest that maternal supplementation for 2 trimesters decreased risk of brain tumor [odds ratio (OR) = 0.7; 95% confidence interval (CI) = 0.5, 0.9], with a trend of less risk with longer duration of use (p trend = 0.0007). The greatest risk reduction was among children diagnosed under 5 years of age whose mothers used supplements during all 3 trimesters (OR = 0.5; CI = 0.3, 0.8). This effect did not vary by histology and was seen for supplementation during pregnancy rather than during the month before pregnancy or while breastfeeding. Our findings are largely driven by data from the United States, where most mothers took vitamins. The proportion of control mothers who took vitamins during pregnancy varied markedly from 3% in Israel and in France, 21% in Italy, 33% in Canada and 52% in Spain to 86-92% at the 3 U.S. centers. The composition of the various multivitamin compounds taken also varied: daily dose of vitamin C ranged from 0 to 600 mg; vitamin E from 0 to 70 mg; vitamin A from 0 to 30,000 IU; and folate from 0 to 2,000 μg. Mothers also took individual micronutrient supplements (e.g., vitamin C tablets), but most mothers who took these also took multivitamins, making it impossible to determine the potential independent effects of these micronutrients.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalInternational Journal of Cancer
Issue numberSUPPL. 11
Publication statusPublished - 1998

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Vitamins
Brain Neoplasms
Mothers
Pregnancy
Micronutrients
Israel
Ascorbic Acid
Odds Ratio
Confidence Intervals
Population Control
Risk Reduction Behavior
North America
Breast Feeding
Vitamin A
Vitamin E
Folic Acid
Spain
Italy
Tablets
France

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Preston-Martin, S., Pogoda, J. M., Mueller, B. A., Lubin, F., Holly, E. A., Filippini, G., ... Arslan, A. (1998). Prenatal vitamin supplementation and risk of childhood brain tumors. International Journal of Cancer, (SUPPL. 11), 17-22.

Prenatal vitamin supplementation and risk of childhood brain tumors. / Preston-Martin, S.; Pogoda, J. M.; Mueller, B. A.; Lubin, F.; Holly, E. A.; Filippini, G.; Cordier, S.; Peris-Bonet, R.; Choi, W.; Little, J.; Arslan, A.

In: International Journal of Cancer, No. SUPPL. 11, 1998, p. 17-22.

Research output: Contribution to journalArticle

Preston-Martin, S, Pogoda, JM, Mueller, BA, Lubin, F, Holly, EA, Filippini, G, Cordier, S, Peris-Bonet, R, Choi, W, Little, J & Arslan, A 1998, 'Prenatal vitamin supplementation and risk of childhood brain tumors', International Journal of Cancer, no. SUPPL. 11, pp. 17-22.
Preston-Martin S, Pogoda JM, Mueller BA, Lubin F, Holly EA, Filippini G et al. Prenatal vitamin supplementation and risk of childhood brain tumors. International Journal of Cancer. 1998;(SUPPL. 11):17-22.
Preston-Martin, S. ; Pogoda, J. M. ; Mueller, B. A. ; Lubin, F. ; Holly, E. A. ; Filippini, G. ; Cordier, S. ; Peris-Bonet, R. ; Choi, W. ; Little, J. ; Arslan, A. / Prenatal vitamin supplementation and risk of childhood brain tumors. In: International Journal of Cancer. 1998 ; No. SUPPL. 11. pp. 17-22.
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