Preoperation chemotherapy

Massimo Aglietta

doi:10.1007/978-88-470-1809-9_6

Preoperation chemotherapy

Massimo Aglietta

Istituto Oncologico Candiolo

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Oxaliplatin and irinotecan have widened the chemotherapy alternatives available to patients with metastatic colorectal cancer, and effective targeted agents have further improved treatment efficacy. Combinations of these drugs have set a new benchmark of survival at ∼20 months, enabling a substantial number of patients who were not candidates for resection to qualify for the procedure. Liver resection after tumor downsizing has yielded encouraging results, although cure is rarely achieved. Based on several theoretical advantages, preoperative chemotherapy is increasingly being used also in patients with resectable disease. However, the debate is still ongoing especially with respect to the oncologic benefits and the numerous drawbacks, including hepatic toxicity and the risk of inducing a complete radiologic response.

Original language	English
Title of host publication	Surgical Treatment of Colorectal Liver Metastases
Publisher	Springer Milan
Pages	75-100
Number of pages	26
ISBN (Print)	9788847018082
DOIs	https://doi.org/10.1007/978-88-470-1809-9_6
Publication status	Published - 2011

ASJC Scopus subject areas

Medicine(all)

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Aglietta, M. (2011). Preoperation chemotherapy. In Surgical Treatment of Colorectal Liver Metastases (pp. 75-100). Springer Milan. https://doi.org/10.1007/978-88-470-1809-9_6

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