Preoperative and postoperative glucose consumption in mesiobasal and lateral temporal lobe epilepsy

M. Hajek, H. G. Wieser, N. Khan, A. Antonini, P. R. Schrott, P. Maguire, H. F. Beer, Klaus L. Leenders

Research output: Contribution to journalArticle

Abstract

We have studied 25 patients with interictal 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) before and after selective surgery for temporal lobe epilepsy (TLE). Based on the findings of the presurgical evaluation, including ictal intracranial EEGs, histopathologic findings, and the postoperative outcome, we classified the patients in three subgroups: (1) patients with TLE of lateral temporal origin (n = 5), (2) patients with mesiobasal limbic TLE associated with mesial gliosis (n = 14), and (3) patients with mesiobasal limbic TLE and small mesial tumors (n = 6). Postoperatively, patients with mesiobasal limbic TLE and mesial gliosis and five of six patients with mesiobasal limbic TLE and mesial tumors were seizure-free; the remaining sixth patient had one generalized seizure. Patients with TLE of lateral temporal origin had more than 90% reduction of seizure frequency. The main postoperative metabolic findings were as follows: (1) marked increase of regional cerebral metabolic rate of glucose (rCMRglu), both in the ipsilateral and, significantly, in the contralateral hemisphere in patients with mesiobasal limbic TLE and mesial gliosis-the changes of brain metabolism were characteristic for patients with the syndrome of “mesial temporal lobe epilepsy” (MTLE); (2) decrease of rCMRglu values in the contralateral mesiobasal temporal lobe (TL) cortex in all patient groups-the reduction of rCMRglu in homologous brain structures contralateral to the operated side provides evidence for stronger interhemispheric connections between both mesial TL structures than were hitherto supposed; and (3) a trend toward a normalization of rCMRglu values in the ipsilateral temporal neocortex 12 months after surgery in patients with MTLE syndrome.

Original languageEnglish
Pages (from-to)2125-2132
Number of pages8
JournalNeurology
Volume44
Issue number11
Publication statusPublished - 1994

Fingerprint

Temporal Lobe Epilepsy
Glucose
Gliosis
Temporal Lobe
Seizures
Neocortex
Fluorodeoxyglucose F18
Brain
Positron-Emission Tomography
Neoplasms

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Hajek, M., Wieser, H. G., Khan, N., Antonini, A., Schrott, P. R., Maguire, P., ... Leenders, K. L. (1994). Preoperative and postoperative glucose consumption in mesiobasal and lateral temporal lobe epilepsy. Neurology, 44(11), 2125-2132.

Preoperative and postoperative glucose consumption in mesiobasal and lateral temporal lobe epilepsy. / Hajek, M.; Wieser, H. G.; Khan, N.; Antonini, A.; Schrott, P. R.; Maguire, P.; Beer, H. F.; Leenders, Klaus L.

In: Neurology, Vol. 44, No. 11, 1994, p. 2125-2132.

Research output: Contribution to journalArticle

Hajek, M, Wieser, HG, Khan, N, Antonini, A, Schrott, PR, Maguire, P, Beer, HF & Leenders, KL 1994, 'Preoperative and postoperative glucose consumption in mesiobasal and lateral temporal lobe epilepsy', Neurology, vol. 44, no. 11, pp. 2125-2132.
Hajek M, Wieser HG, Khan N, Antonini A, Schrott PR, Maguire P et al. Preoperative and postoperative glucose consumption in mesiobasal and lateral temporal lobe epilepsy. Neurology. 1994;44(11):2125-2132.
Hajek, M. ; Wieser, H. G. ; Khan, N. ; Antonini, A. ; Schrott, P. R. ; Maguire, P. ; Beer, H. F. ; Leenders, Klaus L. / Preoperative and postoperative glucose consumption in mesiobasal and lateral temporal lobe epilepsy. In: Neurology. 1994 ; Vol. 44, No. 11. pp. 2125-2132.
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abstract = "We have studied 25 patients with interictal 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) before and after selective surgery for temporal lobe epilepsy (TLE). Based on the findings of the presurgical evaluation, including ictal intracranial EEGs, histopathologic findings, and the postoperative outcome, we classified the patients in three subgroups: (1) patients with TLE of lateral temporal origin (n = 5), (2) patients with mesiobasal limbic TLE associated with mesial gliosis (n = 14), and (3) patients with mesiobasal limbic TLE and small mesial tumors (n = 6). Postoperatively, patients with mesiobasal limbic TLE and mesial gliosis and five of six patients with mesiobasal limbic TLE and mesial tumors were seizure-free; the remaining sixth patient had one generalized seizure. Patients with TLE of lateral temporal origin had more than 90{\%} reduction of seizure frequency. The main postoperative metabolic findings were as follows: (1) marked increase of regional cerebral metabolic rate of glucose (rCMRglu), both in the ipsilateral and, significantly, in the contralateral hemisphere in patients with mesiobasal limbic TLE and mesial gliosis-the changes of brain metabolism were characteristic for patients with the syndrome of “mesial temporal lobe epilepsy” (MTLE); (2) decrease of rCMRglu values in the contralateral mesiobasal temporal lobe (TL) cortex in all patient groups-the reduction of rCMRglu in homologous brain structures contralateral to the operated side provides evidence for stronger interhemispheric connections between both mesial TL structures than were hitherto supposed; and (3) a trend toward a normalization of rCMRglu values in the ipsilateral temporal neocortex 12 months after surgery in patients with MTLE syndrome.",
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