Preoperative antibiotic prophylaxis in flexural surgery of difficult contamination-prone areas of the skin: The utility of a single dose of antibiotic

Pl Bencini, M. Signorini, M. Galimberti, S. Cavicchini, R. Caputo

Research output: Contribution to journalArticle

Abstract

The aim of this multicentre controlled study was to analyse the effect of the timing of antibiotic administration on the preoperative prophylaxis of wound infections in contamination-prone areas of the skin and to verify the utility of a single dose of prophylactic antibiotic compared with other multiple dose schemes. A total of 527 patients were surgically treated for skin neoplasms arising in contamination-prone areas. The four prophylactic programmes, to which the patients were randomly allocated, were as follows: (A) no antibacterial prophylaxis; (B) intramuscular cephazolin, 1 g every 12 h beginning 48 h prior to surgery and continuing for 48 h after surgery; (C) intramuscular cephazolin, 1 g every 12 h beginning 2 h before surgery and continuing 24 h after surgery; and (D) intramuscular cephazolin, 1 g single dose 2 h before surgery. The rate of postoperative infections was: group A 12% group B 4.6% group C 0.77% group D 2.96% Our study confirms the utility of antibiotic prophylaxis in prevention of postoperative infections and demonstrates that brief regimens are superior to more prolonged regimens. In particular, a single dose antibiotic schedule significantly reduces the infection rate, is cheaper, and is better tolerated by the patients.

Original languageEnglish
Pages (from-to)17-19
Number of pages3
JournalJournal of Dermatological Treatment
Volume5
Issue number1
DOIs
Publication statusPublished - 1994

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ASJC Scopus subject areas

  • Dermatology

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