TY - JOUR
T1 - Preoperative CEA, NSE, SCC, TPA and CYFRA 21.1 serum levels as prognostic indicators in resected non-small cell lung cancer
AU - Foa, Paolo
AU - Fornier, M.
AU - Miceli, R.
AU - Seregni, E.
AU - Santambrogio, L.
AU - Nosotti, M.
AU - Massaron, S.
AU - Cataldo, I.
AU - Oldani, S.
AU - Iurlo, A.
AU - Caldiera, S.
AU - Bombardieri, E.
PY - 1999/4
Y1 - 1999/4
N2 - In 62 patients affected by resectable non-small cell lung cancer (NSCLC) submitted to radical surgery, we evaluated the prognostic significance of CEA, NSE, SCC, TPA and CYFRA 21.1 serum levels at diagnosis, as well as the predictive ability of these tumor markers with respect to histological type and pathological stage. The group was composed of 56 male and 6 female patients; the median age was 62 years (range 29-73 years). Thirty-four patients had a histological diagnosis of adenocarcinoma and 28 of squamous cell carcinoma; with regard to pathological stage, 32 patients had stage I, 4 patients stage II and 23 patients stage IIIA disease. A good predictive ability with respect to histological type was obtained with SCC serum levels; as for pathological stage, TPA and CYFRA 21.1 were found to have moderate predictive ability. In this series of patients, at a median follow-up of 55 months after surgery we found that both TPA and CYFRA 21.1 serum levels at diagnosis were reliable predictors of overall survival, high values of these markers being associated with a worse prognosis.
AB - In 62 patients affected by resectable non-small cell lung cancer (NSCLC) submitted to radical surgery, we evaluated the prognostic significance of CEA, NSE, SCC, TPA and CYFRA 21.1 serum levels at diagnosis, as well as the predictive ability of these tumor markers with respect to histological type and pathological stage. The group was composed of 56 male and 6 female patients; the median age was 62 years (range 29-73 years). Thirty-four patients had a histological diagnosis of adenocarcinoma and 28 of squamous cell carcinoma; with regard to pathological stage, 32 patients had stage I, 4 patients stage II and 23 patients stage IIIA disease. A good predictive ability with respect to histological type was obtained with SCC serum levels; as for pathological stage, TPA and CYFRA 21.1 were found to have moderate predictive ability. In this series of patients, at a median follow-up of 55 months after surgery we found that both TPA and CYFRA 21.1 serum levels at diagnosis were reliable predictors of overall survival, high values of these markers being associated with a worse prognosis.
KW - CEA
KW - CYFRA 21.1
KW - Non-small cell lung cancer
KW - NSE
KW - SCC
KW - TPA
UR - http://www.scopus.com/inward/record.url?scp=0033002559&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033002559&partnerID=8YFLogxK
M3 - Article
C2 - 10399628
AN - SCOPUS:0033002559
VL - 14
SP - 92
EP - 98
JO - International Journal of Biological Markers
JF - International Journal of Biological Markers
SN - 0393-6155
IS - 2
ER -