Preoperative circulating sex hormones are not predictors of positive surgical margins at open radical prostatectomy

Andrea Salonia, Andrea Gallina, Firas Abdollah, Alberto Briganti, Umberto Capitanio, Nazareno Suardi, Matteo Ferrari, Marco Raber, Renzo Colombo, Massimo Freschi, Patrizio Rigatti, Francesco Montorsi

Research output: Contribution to journalArticle

Abstract

Purpose: To examine the association between positive surgical margins (PSMs) and preoperative circulating estradiol (E2), total testosterone (tT), and sex hormone-binding globulin (SHBG) in patients undergoing retropubic radical prostatectomy (RRP). Methods: A cohort of 665 non-screened patients who underwent RRP at a single institute was studied. Serum tT, E2, and SHBG were measured the day before surgery (8-10 am) in all cases. Logistic regression models tested the association between predictors [e. g., PSA, clinical stage, biopsy Gleason sum, body mass index (BMI), tT, E2, and SHBG] and PSM. Circulating tT was included in the model as both a continuous variable and a categorized variable [according to the definition of hypogonadism (2, and SHBG between patients with and without PSMs. At multivariate analysis, tT, hypogonadism, E2, and SHBG were not significantly associated with PSMs, after accounting for routinely available preoperative parameters. Conclusions: In contrast to previously published data, preoperative tT was not an independent predictive factor for PSM at RRP. Likewise, hypogonadism, E2, and SHBG did not achieve independent predictor status for PSM, after accounting for routinely available preoperative parameters.

Original languageEnglish
Pages (from-to)533-539
Number of pages7
JournalWorld Journal of Urology
Volume30
Issue number4
DOIs
Publication statusPublished - 2012

Keywords

  • Estradiol
  • Hypogonadism
  • Positive surgical margins
  • Prostate cancer
  • Radical prostatectomy
  • Testosterone

ASJC Scopus subject areas

  • Urology

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