Preoperative locoregional staging of gastric cancer: is there a place for magnetic resonance imaging? Prospective comparison with EUS and multidetector computed tomography

Francesco Giganti, Elena Orsenigo, Paolo Giorgio Arcidiacono, Roberto Nicoletti, Luca Albarello, Alessandro Ambrosi, Annalaura Salerno, Antonio Esposito, Maria Chiara Petrone, Damiano Chiari, Carlo Staudacher, Alessandro Del Maschio, Francesco De Cobelli

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The aim of this study was to prospectively compare the diagnostic performance of magnetic resonance imaging (MRI), multidetector computed tomography (MDCT) and endoscopic ultrasonography (EUS) in the preoperative locoregional staging of gastric cancer. Methods: This study had Institutional Review Board approval, and informed consent was obtained from all patients. Fifty-two patients with biopsy-proven gastric cancer underwent preoperative 1.5-T MRI, 64-channel MDCT and EUS. All images were analysed blind, and the results were compared with histopathological findings according to the seventh edition of the TNM classification. After the population had been divided on the basis of the local invasion (T1-3 vs T4a-b) and nodal involvement (N0 vs N+), sensitivity, specificity, positive and negative predictive value, and accuracy were calculated and diagnostic performance measures were assessed using the McNemar test. Results: For T staging, EUS showed higher sensitivity (94 %) than MDCT and MRI (65 and 76 %; p = 0.02 and p = 0.08). MDCT and MRI had significantly higher specificity (91 and 89 %) than EUS (60 %) (p = 0.0009 and p = 0.003). Adding MRI to MDCT or EUS did not result in significant differences for sensitivity. For N staging, EUS showed higher sensitivity (92 %) than MRI and MDCT (69 and 73 %; p = 0.01 and p = 0.02). MDCT showed better specificity (81 %) than EUS and MRI (58 and 73 %; p = 0.03 and p = 0.15). Conclusions: Our prospective study confirmed the leading role of EUS and MDCT in the staging of gastric cancer and did not prove, at present, the value of the clinical use of MRI.

Original languageEnglish
Pages (from-to)216-225
Number of pages10
JournalGastric Cancer
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • Endoscopic ultrasonography
  • Gastric cancer
  • Magnetic resonance imaging
  • Multidetector computed tomography
  • TNM staging

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Cancer Research

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