Preoperative prostate-specific antigen isoform p2PSA and its derivatives, %p2PSA and prostate health index, predict pathologic outcomes in patients undergoing radical prostatectomy for prostate cancer

Giorgio Guazzoni; Massimo Lazzeri; Luciano Nava; Giovanni Lughezzani; Alessandro Larcher; Vincenzo Scattoni; Giulio Maria Gadda; Vittorio Bini; Andrea Cestari; Nicol Maria Buffi; Massimo Freschi; Patrizio Rigatti; Francesco Montorsi

doi:10.1016/j.eururo.2011.10.038

Preoperative prostate-specific antigen isoform p2PSA and its derivatives, %p2PSA and prostate health index, predict pathologic outcomes in patients undergoing radical prostatectomy for prostate cancer

Giorgio Guazzoni, Massimo Lazzeri, Luciano Nava, Giovanni Lughezzani, Alessandro Larcher, Vincenzo Scattoni, Giulio Maria Gadda, Vittorio Bini, Andrea Cestari, Nicol Maria Buffi, Massimo Freschi, Patrizio Rigatti, Francesco Montorsi

Research output: Contribution to journal › Article

Abstract

Background: Currently available predictive models fail to assist clinical decision making in prostate cancer (PCa) patients who are possible candidates for radical prostatectomy (RP). New biomarkers would be welcome. Objective: Test the hypothesis that prostate-specific antigen (PSA) isoform p2PSA and its derivates, percentage of p2PSA to free PSA (%p2PSA) and the Prostate Health Index (PHI), predict PCa characteristics at final pathology after RP. Design, setting, and participants: An observational prospective study was performed in 350 consecutive men diagnosed with clinically localised PCa who underwent RP. Measurements: We determined the predictive accuracy of serum total PSA (tPSA), free PSA (fPSA), fPSA-to-tPSA ratio (%fPSA), p2PSA, %p2PSA, and PHI. The primary end point was to determine the accuracy of these biomarkers in predicting the presence of pT3 disease, pathologic Gleason sum ≥7, Gleason sum upgrading, and tumour volume

Original language	English
Pages (from-to)	455-466
Number of pages	12
Journal	European Urology
Volume	61
Issue number	3
DOIs	https://doi.org/10.1016/j.eururo.2011.10.038
Publication status	Published - Mar 2012

Keywords

[-2]proPSA
Pathologic examination
Predictive models
Prostate cancer
Prostate health index
Prostate-specific antigen
Radical prostatectomy

ASJC Scopus subject areas

Urology

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Guazzoni, G., Lazzeri, M., Nava, L., Lughezzani, G., Larcher, A., Scattoni, V., Gadda, G. M., Bini, V., Cestari, A., Buffi, N. M., Freschi, M., Rigatti, P., & Montorsi, F. (2012). Preoperative prostate-specific antigen isoform p2PSA and its derivatives, %p2PSA and prostate health index, predict pathologic outcomes in patients undergoing radical prostatectomy for prostate cancer. European Urology, 61(3), 455-466. https://doi.org/10.1016/j.eururo.2011.10.038

Preoperative prostate-specific antigen isoform p2PSA and its derivatives, %p2PSA and prostate health index, predict pathologic outcomes in patients undergoing radical prostatectomy for prostate cancer. / Guazzoni, Giorgio; Lazzeri, Massimo; Nava, Luciano; Lughezzani, Giovanni; Larcher, Alessandro; Scattoni, Vincenzo; Gadda, Giulio Maria; Bini, Vittorio; Cestari, Andrea; Buffi, Nicol Maria; Freschi, Massimo; Rigatti, Patrizio; Montorsi, Francesco.

In: European Urology, Vol. 61, No. 3, 03.2012, p. 455-466.

Research output: Contribution to journal › Article

Guazzoni, G, Lazzeri, M, Nava, L, Lughezzani, G, Larcher, A, Scattoni, V, Gadda, GM, Bini, V, Cestari, A, Buffi, NM, Freschi, M, Rigatti, P & Montorsi, F 2012, 'Preoperative prostate-specific antigen isoform p2PSA and its derivatives, %p2PSA and prostate health index, predict pathologic outcomes in patients undergoing radical prostatectomy for prostate cancer', European Urology, vol. 61, no. 3, pp. 455-466. https://doi.org/10.1016/j.eururo.2011.10.038

Guazzoni, Giorgio ; Lazzeri, Massimo ; Nava, Luciano ; Lughezzani, Giovanni ; Larcher, Alessandro ; Scattoni, Vincenzo ; Gadda, Giulio Maria ; Bini, Vittorio ; Cestari, Andrea ; Buffi, Nicol Maria ; Freschi, Massimo ; Rigatti, Patrizio ; Montorsi, Francesco. / Preoperative prostate-specific antigen isoform p2PSA and its derivatives, %p2PSA and prostate health index, predict pathologic outcomes in patients undergoing radical prostatectomy for prostate cancer. In: European Urology. 2012 ; Vol. 61, No. 3. pp. 455-466.

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abstract = "Background: Currently available predictive models fail to assist clinical decision making in prostate cancer (PCa) patients who are possible candidates for radical prostatectomy (RP). New biomarkers would be welcome. Objective: Test the hypothesis that prostate-specific antigen (PSA) isoform p2PSA and its derivates, percentage of p2PSA to free PSA (%p2PSA) and the Prostate Health Index (PHI), predict PCa characteristics at final pathology after RP. Design, setting, and participants: An observational prospective study was performed in 350 consecutive men diagnosed with clinically localised PCa who underwent RP. Measurements: We determined the predictive accuracy of serum total PSA (tPSA), free PSA (fPSA), fPSA-to-tPSA ratio (%fPSA), p2PSA, %p2PSA, and PHI. The primary end point was to determine the accuracy of these biomarkers in predicting the presence of pT3 disease, pathologic Gleason sum ≥7, Gleason sum upgrading, and tumour volume ",

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AU - Lazzeri, Massimo

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AU - Lughezzani, Giovanni

AU - Larcher, Alessandro

AU - Scattoni, Vincenzo

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AU - Bini, Vittorio

AU - Cestari, Andrea

AU - Buffi, Nicol Maria

AU - Freschi, Massimo

AU - Rigatti, Patrizio

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