TY - JOUR
T1 - Preoperative prostate-specific antigen isoform p2PSA and its derivatives, %p2PSA and prostate health index, predict pathologic outcomes in patients undergoing radical prostatectomy for prostate cancer
AU - Guazzoni, Giorgio
AU - Lazzeri, Massimo
AU - Nava, Luciano
AU - Lughezzani, Giovanni
AU - Larcher, Alessandro
AU - Scattoni, Vincenzo
AU - Gadda, Giulio Maria
AU - Bini, Vittorio
AU - Cestari, Andrea
AU - Buffi, Nicol Maria
AU - Freschi, Massimo
AU - Rigatti, Patrizio
AU - Montorsi, Francesco
PY - 2012/3
Y1 - 2012/3
N2 - Background: Currently available predictive models fail to assist clinical decision making in prostate cancer (PCa) patients who are possible candidates for radical prostatectomy (RP). New biomarkers would be welcome. Objective: Test the hypothesis that prostate-specific antigen (PSA) isoform p2PSA and its derivates, percentage of p2PSA to free PSA (%p2PSA) and the Prostate Health Index (PHI), predict PCa characteristics at final pathology after RP. Design, setting, and participants: An observational prospective study was performed in 350 consecutive men diagnosed with clinically localised PCa who underwent RP. Measurements: We determined the predictive accuracy of serum total PSA (tPSA), free PSA (fPSA), fPSA-to-tPSA ratio (%fPSA), p2PSA, %p2PSA, and PHI. The primary end point was to determine the accuracy of these biomarkers in predicting the presence of pT3 disease, pathologic Gleason sum ≥7, Gleason sum upgrading, and tumour volume
AB - Background: Currently available predictive models fail to assist clinical decision making in prostate cancer (PCa) patients who are possible candidates for radical prostatectomy (RP). New biomarkers would be welcome. Objective: Test the hypothesis that prostate-specific antigen (PSA) isoform p2PSA and its derivates, percentage of p2PSA to free PSA (%p2PSA) and the Prostate Health Index (PHI), predict PCa characteristics at final pathology after RP. Design, setting, and participants: An observational prospective study was performed in 350 consecutive men diagnosed with clinically localised PCa who underwent RP. Measurements: We determined the predictive accuracy of serum total PSA (tPSA), free PSA (fPSA), fPSA-to-tPSA ratio (%fPSA), p2PSA, %p2PSA, and PHI. The primary end point was to determine the accuracy of these biomarkers in predicting the presence of pT3 disease, pathologic Gleason sum ≥7, Gleason sum upgrading, and tumour volume
KW - [-2]proPSA
KW - Pathologic examination
KW - Predictive models
KW - Prostate cancer
KW - Prostate health index
KW - Prostate-specific antigen
KW - Radical prostatectomy
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U2 - 10.1016/j.eururo.2011.10.038
DO - 10.1016/j.eururo.2011.10.038
M3 - Article
C2 - 22078333
AN - SCOPUS:84856374086
VL - 61
SP - 455
EP - 466
JO - European Urology
JF - European Urology
SN - 0302-2838
IS - 3
ER -