Preoperative radiotherapy for resectable cancer of the middle-distal rectum: Its effect on the primary lesion as determined by endorectal ultrasound using flexible echo colonoscope

F. Bozzetti, S. Andreola, C. Rossetti, R. Zucali, E. Meroni, D. Baratti, L. Bertario, R. Doci, L. Gennari

Research output: Contribution to journalArticle

Abstract

20 patients with rectal cancer within 8 cm of the anal verge were studied. Endoscopic endosonography was carried out before and after pre-operative radiotherapy (45 Gy over three weeks). The local extent (tumour stage and diameter) was compared with the results of his topathological examination of the resected specimen after anterior resection [12] or total rectal excision [8]. The Tumour Regression Grade (TRG) and lymph node status were also estimated. Two patients were not evaluated endosonographically. Two (11%) of the remaining 18 patients showed ultrasound evidence of down staging (14/18 uT3/4 pre-radiotherapy: 12/18 uT3/4 after) and tumour diameter was significantly reduced. Tumour Regression Grade estimation showed evidence of response to treatment, showing regression of more than 50% in 13 (65%) of cases. Involved nodes were less than 5 mm in diameter in 45% of cases. Histopathological evidence of nodal metastatic regression was seen in 13 (28%) of all involved nodes found. The ultrasonically determined response to radiotherapy may offer useful information in predicting outcome and possibly in selecting surgery.

Original languageEnglish
Pages (from-to)283-286
Number of pages4
JournalInternational Journal of Colorectal Disease
Volume11
Issue number6
DOIs
Publication statusPublished - Dec 1996

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Preoperative radiotherapy for resectable cancer of the middle-distal rectum: Its effect on the primary lesion as determined by endorectal ultrasound using flexible echo colonoscope'. Together they form a unique fingerprint.

  • Cite this