Abstract
Despite the efficacy of IL-2 in the treatment of metastatic renal cell carcinoma (RCC), the prognosis of patients with synchronous metastases still remains poor. Nephrectomy itself, as well as other surgical operations, may further suppress the antitumor immune response. Previous studies suggested that the preoperative injection of IL-2 may neutralize surgery-induced lymphocytopenia in advanced colon cancer. On this basis, a pilot randomized study was performed in an attempt to evaluate the effects of a preoperative administration of IL-2 on postoperative lymphocyte numbers and on the survival in advanced RVV patients with more than 3 synchronous metastases. The study included 20 consecutive patients, who were randomized to receive nephrectomy alone or nephrectomy plus preoperative subcutaneous immunotherapy with IL-2 (18 million IU/day for 3 days). Then, all patients underwent postoperative immunotherapy with IL-2 (6 million IU/day for 5 days/week for 6 weeks). Surgery-induced lymphocytopenia was completely abolished by IL-2 preoperative injection. The frequency of postoperative complications was significantly higher in controls than in patients preoperatively treated with IL-2. On the contrary, significant differences between control and patients preoperatively treated with IL-2 were observed neither in the clinical response to IL-2 immunotherapy, nor in the percent of 1-year survival. The results of this preliminary pilot study would suggest that IL-2 preoperative immunotherapy may neutralize surgery-induced lymphocytopenia and reduce the postoperative complications in RCC patients with synchronous metastases, without, however, influencing their prognosis in terms of survival time.
| Original language | Italian |
|---|---|
| Pages (from-to) | 49-54 |
| Number of pages | 6 |
| Journal | Archivio Italiano di Urologia e Andrologia |
| Volume | 69 |
| Issue number | 1 |
| Publication status | Published - 1997 |
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ASJC Scopus subject areas
- Nephrology
- Urology
Cite this
Immunoterapia sottocutanea preoperatoria con interleuchina-2 nel carcinoma renale con piu sedi metastatiche sincrone : Studio randomizzato clinico-biologico. / Scardino, E.; Lissoni, P.; Andres, M.; Frea, B.; Favini, P.; Kocjancic, E.; Verweij, F.; Barni, S.; Tancini, G.; Rocco, F.
In: Archivio Italiano di Urologia e Andrologia, Vol. 69, No. 1, 1997, p. 49-54.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunoterapia sottocutanea preoperatoria con interleuchina-2 nel carcinoma renale con piu sedi metastatiche sincrone
T2 - Studio randomizzato clinico-biologico
AU - Scardino, E.
AU - Lissoni, P.
AU - Andres, M.
AU - Frea, B.
AU - Favini, P.
AU - Kocjancic, E.
AU - Verweij, F.
AU - Barni, S.
AU - Tancini, G.
AU - Rocco, F.
PY - 1997
Y1 - 1997
N2 - Despite the efficacy of IL-2 in the treatment of metastatic renal cell carcinoma (RCC), the prognosis of patients with synchronous metastases still remains poor. Nephrectomy itself, as well as other surgical operations, may further suppress the antitumor immune response. Previous studies suggested that the preoperative injection of IL-2 may neutralize surgery-induced lymphocytopenia in advanced colon cancer. On this basis, a pilot randomized study was performed in an attempt to evaluate the effects of a preoperative administration of IL-2 on postoperative lymphocyte numbers and on the survival in advanced RVV patients with more than 3 synchronous metastases. The study included 20 consecutive patients, who were randomized to receive nephrectomy alone or nephrectomy plus preoperative subcutaneous immunotherapy with IL-2 (18 million IU/day for 3 days). Then, all patients underwent postoperative immunotherapy with IL-2 (6 million IU/day for 5 days/week for 6 weeks). Surgery-induced lymphocytopenia was completely abolished by IL-2 preoperative injection. The frequency of postoperative complications was significantly higher in controls than in patients preoperatively treated with IL-2. On the contrary, significant differences between control and patients preoperatively treated with IL-2 were observed neither in the clinical response to IL-2 immunotherapy, nor in the percent of 1-year survival. The results of this preliminary pilot study would suggest that IL-2 preoperative immunotherapy may neutralize surgery-induced lymphocytopenia and reduce the postoperative complications in RCC patients with synchronous metastases, without, however, influencing their prognosis in terms of survival time.
AB - Despite the efficacy of IL-2 in the treatment of metastatic renal cell carcinoma (RCC), the prognosis of patients with synchronous metastases still remains poor. Nephrectomy itself, as well as other surgical operations, may further suppress the antitumor immune response. Previous studies suggested that the preoperative injection of IL-2 may neutralize surgery-induced lymphocytopenia in advanced colon cancer. On this basis, a pilot randomized study was performed in an attempt to evaluate the effects of a preoperative administration of IL-2 on postoperative lymphocyte numbers and on the survival in advanced RVV patients with more than 3 synchronous metastases. The study included 20 consecutive patients, who were randomized to receive nephrectomy alone or nephrectomy plus preoperative subcutaneous immunotherapy with IL-2 (18 million IU/day for 3 days). Then, all patients underwent postoperative immunotherapy with IL-2 (6 million IU/day for 5 days/week for 6 weeks). Surgery-induced lymphocytopenia was completely abolished by IL-2 preoperative injection. The frequency of postoperative complications was significantly higher in controls than in patients preoperatively treated with IL-2. On the contrary, significant differences between control and patients preoperatively treated with IL-2 were observed neither in the clinical response to IL-2 immunotherapy, nor in the percent of 1-year survival. The results of this preliminary pilot study would suggest that IL-2 preoperative immunotherapy may neutralize surgery-induced lymphocytopenia and reduce the postoperative complications in RCC patients with synchronous metastases, without, however, influencing their prognosis in terms of survival time.
KW - immunosuppression
KW - immunotherapy
KW - interleukin-2
KW - lymphocytopenia
KW - renal cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=0030748727&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030748727&partnerID=8YFLogxK
M3 - Articolo
C2 - 9181906
AN - SCOPUS:0030748727
VL - 69
SP - 49
EP - 54
JO - Archivio Italiano di Urologia Nefrologia Andrologia
JF - Archivio Italiano di Urologia Nefrologia Andrologia
SN - 1120-8538
IS - 1
ER -