Preparation and Antiproliferative Activity of Liposomes Containing a Combination of Cisplatin and Procainamide Hydrochloride

Maurizio Viale, Antonella Fontana, Irena Maric, Massimiliano Monticone, Guido Angelini, Carla Gasbarri

Research output: Contribution to journalArticlepeer-review

Abstract

We have previously reported the enhancement of the antiproliferative and apoptotic activities of cis-diamminedichloroplatinum(II) (DDP) when it is coadministered with a class I antiarrhythmic drug procainamide hydrochloride (PA). Here, we determined the antiproliferative activity of DDP, either in solution or loaded in liposomes, in the presence of PA, in the bulk solution, or directly embedded in liposomes together with DDP. Our results show that PA potentiates the activity of DDP-liposomes and that this effect is maintained at least in some of the investigated cell types when both drugs were mixed and loaded together into liposomes.

Original languageEnglish
Pages (from-to)1393-1395
Number of pages3
JournalChemical Research in Toxicology
Volume29
Issue number9
DOIs
Publication statusPublished - Sep 19 2016

ASJC Scopus subject areas

  • Toxicology

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