Abstract
We have previously reported the enhancement of the antiproliferative and apoptotic activities of cis-diamminedichloroplatinum(II) (DDP) when it is coadministered with a class I antiarrhythmic drug procainamide hydrochloride (PA). Here, we determined the antiproliferative activity of DDP, either in solution or loaded in liposomes, in the presence of PA, in the bulk solution, or directly embedded in liposomes together with DDP. Our results show that PA potentiates the activity of DDP-liposomes and that this effect is maintained at least in some of the investigated cell types when both drugs were mixed and loaded together into liposomes.
| Original language | English |
|---|---|
| Pages (from-to) | 1393-1395 |
| Number of pages | 3 |
| Journal | Chemical Research in Toxicology |
| Volume | 29 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 19 2016 |
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ASJC Scopus subject areas
- Toxicology
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Preparation and Antiproliferative Activity of Liposomes Containing a Combination of Cisplatin and Procainamide Hydrochloride. / Viale, Maurizio; Fontana, Antonella; Maric, Irena; Monticone, Massimiliano; Angelini, Guido; Gasbarri, Carla.
In: Chemical Research in Toxicology, Vol. 29, No. 9, 19.09.2016, p. 1393-1395.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Preparation and Antiproliferative Activity of Liposomes Containing a Combination of Cisplatin and Procainamide Hydrochloride
AU - Viale, Maurizio
AU - Fontana, Antonella
AU - Maric, Irena
AU - Monticone, Massimiliano
AU - Angelini, Guido
AU - Gasbarri, Carla
PY - 2016/9/19
Y1 - 2016/9/19
N2 - We have previously reported the enhancement of the antiproliferative and apoptotic activities of cis-diamminedichloroplatinum(II) (DDP) when it is coadministered with a class I antiarrhythmic drug procainamide hydrochloride (PA). Here, we determined the antiproliferative activity of DDP, either in solution or loaded in liposomes, in the presence of PA, in the bulk solution, or directly embedded in liposomes together with DDP. Our results show that PA potentiates the activity of DDP-liposomes and that this effect is maintained at least in some of the investigated cell types when both drugs were mixed and loaded together into liposomes.
AB - We have previously reported the enhancement of the antiproliferative and apoptotic activities of cis-diamminedichloroplatinum(II) (DDP) when it is coadministered with a class I antiarrhythmic drug procainamide hydrochloride (PA). Here, we determined the antiproliferative activity of DDP, either in solution or loaded in liposomes, in the presence of PA, in the bulk solution, or directly embedded in liposomes together with DDP. Our results show that PA potentiates the activity of DDP-liposomes and that this effect is maintained at least in some of the investigated cell types when both drugs were mixed and loaded together into liposomes.
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U2 - 10.1021/acs.chemrestox.6b00207
DO - 10.1021/acs.chemrestox.6b00207
M3 - Article
VL - 29
SP - 1393
EP - 1395
JO - Chemical Research in Toxicology
JF - Chemical Research in Toxicology
SN - 0893-228X
IS - 9
ER -