Abstract
Technetium-99m labeled bis(1,2-diethylphosphino)ethane was evaluated as a cardiac perfusion agent in mice, dogs and normal human volunteers. The agent produced as a single cationic compound was prepared by a simple kit type method and had a rapid myocardial uptake in animals. The cardiac uptake of the agent in dogs averaged 4.6% of administered dose and delineated left and right ventricles by in vivo imaging. In dogs with experimental myocardial infarction, the agent was distributed according to the regional myocardial blood flow, had excellent correlation with myocardial distribution of 85Sr microspheres (r = 0.96, 0.93)] and 201Tl (r = 0.91 and 0.83), and enabled us to detect perfusion defects by in vivo scintigraphy. The agent, however, failed to have a useful degree of cardiac uptake in humans.
| Original language | English |
|---|---|
| Pages (from-to) | 507-515 |
| Number of pages | 9 |
| Journal | The International Journal Of Applied Radiation And Isotopes |
| Volume | 35 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1984 |
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ASJC Scopus subject areas
- Nuclear Energy and Engineering
- Radiology Nuclear Medicine and imaging
- Radiation
Cite this
Preparation and evaluation of [99mTc]DEPE as a cardiac perfusion agent. / Thakur, M. L.; Park, C. H.; Fazio, F.; Gerundini, P.; Margonato, A.; Vicedomini, G.; Colombo, R.; Colombo, F.; Gilardi, M.; Fregoso, F.; Bencivelli, R.; Taddei, G.
In: The International Journal Of Applied Radiation And Isotopes, Vol. 35, No. 6, 1984, p. 507-515.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Preparation and evaluation of [99mTc]DEPE as a cardiac perfusion agent
AU - Thakur, M. L.
AU - Park, C. H.
AU - Fazio, F.
AU - Gerundini, P.
AU - Margonato, A.
AU - Vicedomini, G.
AU - Colombo, R.
AU - Colombo, F.
AU - Gilardi, M.
AU - Fregoso, F.
AU - Bencivelli, R.
AU - Taddei, G.
PY - 1984
Y1 - 1984
N2 - Technetium-99m labeled bis(1,2-diethylphosphino)ethane was evaluated as a cardiac perfusion agent in mice, dogs and normal human volunteers. The agent produced as a single cationic compound was prepared by a simple kit type method and had a rapid myocardial uptake in animals. The cardiac uptake of the agent in dogs averaged 4.6% of administered dose and delineated left and right ventricles by in vivo imaging. In dogs with experimental myocardial infarction, the agent was distributed according to the regional myocardial blood flow, had excellent correlation with myocardial distribution of 85Sr microspheres (r = 0.96, 0.93)] and 201Tl (r = 0.91 and 0.83), and enabled us to detect perfusion defects by in vivo scintigraphy. The agent, however, failed to have a useful degree of cardiac uptake in humans.
AB - Technetium-99m labeled bis(1,2-diethylphosphino)ethane was evaluated as a cardiac perfusion agent in mice, dogs and normal human volunteers. The agent produced as a single cationic compound was prepared by a simple kit type method and had a rapid myocardial uptake in animals. The cardiac uptake of the agent in dogs averaged 4.6% of administered dose and delineated left and right ventricles by in vivo imaging. In dogs with experimental myocardial infarction, the agent was distributed according to the regional myocardial blood flow, had excellent correlation with myocardial distribution of 85Sr microspheres (r = 0.96, 0.93)] and 201Tl (r = 0.91 and 0.83), and enabled us to detect perfusion defects by in vivo scintigraphy. The agent, however, failed to have a useful degree of cardiac uptake in humans.
UR - http://www.scopus.com/inward/record.url?scp=0021287759&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021287759&partnerID=8YFLogxK
U2 - 10.1016/0020-708X(84)90172-8
DO - 10.1016/0020-708X(84)90172-8
M3 - Article
C2 - 6466417
AN - SCOPUS:0021287759
VL - 35
SP - 507
EP - 515
JO - International Journal of Applied Radiation and Isotopes
JF - International Journal of Applied Radiation and Isotopes
SN - 0020-708X
IS - 6
ER -