Preparation and evaluation of [99mTc]DEPE as a cardiac perfusion agent

M. L. Thakur, C. H. Park, F. Fazio, P. Gerundini, A. Margonato, G. Vicedomini, R. Colombo, F. Colombo, M. Gilardi, F. Fregoso, R. Bencivelli, G. Taddei

Research output: Contribution to journalArticlepeer-review

Abstract

Technetium-99m labeled bis(1,2-diethylphosphino)ethane was evaluated as a cardiac perfusion agent in mice, dogs and normal human volunteers. The agent produced as a single cationic compound was prepared by a simple kit type method and had a rapid myocardial uptake in animals. The cardiac uptake of the agent in dogs averaged 4.6% of administered dose and delineated left and right ventricles by in vivo imaging. In dogs with experimental myocardial infarction, the agent was distributed according to the regional myocardial blood flow, had excellent correlation with myocardial distribution of 85Sr microspheres (r = 0.96, 0.93)] and 201Tl (r = 0.91 and 0.83), and enabled us to detect perfusion defects by in vivo scintigraphy. The agent, however, failed to have a useful degree of cardiac uptake in humans.

Original languageEnglish
Pages (from-to)507-515
Number of pages9
JournalThe International Journal Of Applied Radiation And Isotopes
Volume35
Issue number6
DOIs
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Radiation

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