Abstract
A simple method has been developed for the synthesis of 4,4'-diaminodiphenylmethane-(2H4) for analytical purposes in gas chromatography-negative ion chemical ionization mass spectrometry (GC-NICIMS). It consists in a proton-deuterium exchange reaction of the diamine using deutero-hydrochloric acid in deuterated methanol. The reaction was conducted at 60°C. Deuteration of the diamine in the ortho positions of the aromatic rings was observed after eight days in these conditions, using mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy.
| Original language | English |
|---|---|
| Pages (from-to) | 725-728 |
| Number of pages | 4 |
| Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
| Volume | 29 |
| Issue number | 6 |
| Publication status | Published - 1991 |
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ASJC Scopus subject areas
- Analytical Chemistry
- Drug Discovery
- Organic Chemistry
- Clinical Biochemistry
- Molecular Medicine
- Pharmacology
Cite this
Natangelo, M., Bagnati, R., Fanelli, R., Gavinelli, M., Ulbricht, C., & Benfenati, E. (1991). Preparation of 4,4'-diaminodiphenylmethane-(2H4) for use as internal standard in the quantification of 4,4'-diaminodiphenylmethane. Journal of Labelled Compounds and Radiopharmaceuticals, 29(6), 725-728.