Prescribing practice and off-label use of psychotropic medications in post-acute brain injury rehabilitation centres: A cross-sectional survey

Federica Edith Pisa, Giorgia Cosano, Manuela Giangreco, Tullio Giorgini, Emanuele Biasutti, Fabio Barbone, R. Formisano, M. G. Buzzi, C. Pistarini, B. Aiachini, N. Basaglia, A. Montis, L. F. Lucca, F. Lombardi, E. Ranza, M. Vallasciani, A. Celentano, A. Naldi, G. Castellani, G. LambertiB. Lanzillo, F. Posteraro, F. Logi, F. Molteni, M. Lanfranchi, C. Gramigna, G. Bertagnoni, P. Dell'Oste, P. Tonin, V. Iaia, F. Posteraro, L. Sagliocco, M. Beatrici, N. Giunta, T. Dore, G. Galardi, N. Sant'Angelo, R. Piperno, A. Battistini, M. Zampolini, F. Scarponi, V. Sanna, A. M. Biella, S. Premoselli, F. Zaro, K. Bernasconi, M. Carnovali, S. Chierici, R. Antenucci, G. P. Salvi, N. Mazzini, F. Ventura, M. C. Lonati, R. Brianti, P. Mammi, G. Molinero, A. De Tanti, C. Bertolino, P. Boldrini, S. Bargellesi, P. Boldrini, A. Tessari

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: Guidance on pharmacotherapy of neurobehavioural sequelae post-acquired brain injury (ABI) is limited. Clinicians face the choice of prescribing off-label. This survey assesses prescribing practice and off-label use of psychotropic medications in Italian brain injury rehabilitation centres and factors associated with atypical antipsychotics use. Materials and methods: Centres were identified through the roster of the Italian Society for Rehabilitation Medicine. Information was collected through a structured questionnaire. This study calculated the prevalence of centres reporting to use off-label individual medications and unconditional logistic regression Odds Ratio (OR), with 95% confidence interval (95% CI) of atypical antipsychotics use. Results: Psychotropic medications were commonly used. More than 50% of the 35 centres (participation ratio 87.5%) reported to use off-label selected antipsychotics, mostly for agitation (90.5%) and behavioural disturbances (19.0%), and antidepressants, mostly for insomnia (37.5%) and pain (25.0%). Atypical antipsychotic use was directly associated with age

Original languageEnglish
Pages (from-to)508-516
Number of pages9
JournalBrain Injury
Volume29
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

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Off-Label Use
Rehabilitation Centers
Brain Injuries
Antipsychotic Agents
Cross-Sectional Studies
Sleep Initiation and Maintenance Disorders
Antidepressive Agents
Rehabilitation
Logistic Models
Odds Ratio
Medicine
Confidence Intervals
Drug Therapy
Pain
Medication
Brain Injury
Surveys and Questionnaires

Keywords

  • Acquired brain injuries
  • Antidepressants
  • Antiepileptic agents
  • Antipsychotics
  • Off-label
  • Pharmacoepidemiology
  • Prescribing
  • Prevalence
  • Psychotropic medications
  • Survey

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology

Cite this

Prescribing practice and off-label use of psychotropic medications in post-acute brain injury rehabilitation centres : A cross-sectional survey. / Pisa, Federica Edith; Cosano, Giorgia; Giangreco, Manuela; Giorgini, Tullio; Biasutti, Emanuele; Barbone, Fabio; Formisano, R.; Buzzi, M. G.; Pistarini, C.; Aiachini, B.; Basaglia, N.; Montis, A.; Lucca, L. F.; Lombardi, F.; Ranza, E.; Vallasciani, M.; Celentano, A.; Naldi, A.; Castellani, G.; Lamberti, G.; Lanzillo, B.; Posteraro, F.; Logi, F.; Molteni, F.; Lanfranchi, M.; Gramigna, C.; Bertagnoni, G.; Dell'Oste, P.; Tonin, P.; Iaia, V.; Posteraro, F.; Sagliocco, L.; Beatrici, M.; Giunta, N.; Dore, T.; Galardi, G.; Sant'Angelo, N.; Piperno, R.; Battistini, A.; Zampolini, M.; Scarponi, F.; Sanna, V.; Biella, A. M.; Premoselli, S.; Zaro, F.; Bernasconi, K.; Carnovali, M.; Chierici, S.; Antenucci, R.; Salvi, G. P.; Mazzini, N.; Ventura, F.; Lonati, M. C.; Brianti, R.; Mammi, P.; Molinero, G.; De Tanti, A.; Bertolino, C.; Boldrini, P.; Bargellesi, S.; Boldrini, P.; Tessari, A.

In: Brain Injury, Vol. 29, No. 4, 01.04.2015, p. 508-516.

Research output: Contribution to journalArticle

Pisa, FE, Cosano, G, Giangreco, M, Giorgini, T, Biasutti, E, Barbone, F, Formisano, R, Buzzi, MG, Pistarini, C, Aiachini, B, Basaglia, N, Montis, A, Lucca, LF, Lombardi, F, Ranza, E, Vallasciani, M, Celentano, A, Naldi, A, Castellani, G, Lamberti, G, Lanzillo, B, Posteraro, F, Logi, F, Molteni, F, Lanfranchi, M, Gramigna, C, Bertagnoni, G, Dell'Oste, P, Tonin, P, Iaia, V, Posteraro, F, Sagliocco, L, Beatrici, M, Giunta, N, Dore, T, Galardi, G, Sant'Angelo, N, Piperno, R, Battistini, A, Zampolini, M, Scarponi, F, Sanna, V, Biella, AM, Premoselli, S, Zaro, F, Bernasconi, K, Carnovali, M, Chierici, S, Antenucci, R, Salvi, GP, Mazzini, N, Ventura, F, Lonati, MC, Brianti, R, Mammi, P, Molinero, G, De Tanti, A, Bertolino, C, Boldrini, P, Bargellesi, S, Boldrini, P & Tessari, A 2015, 'Prescribing practice and off-label use of psychotropic medications in post-acute brain injury rehabilitation centres: A cross-sectional survey', Brain Injury, vol. 29, no. 4, pp. 508-516. https://doi.org/10.3109/02699052.2014.992474
Pisa, Federica Edith ; Cosano, Giorgia ; Giangreco, Manuela ; Giorgini, Tullio ; Biasutti, Emanuele ; Barbone, Fabio ; Formisano, R. ; Buzzi, M. G. ; Pistarini, C. ; Aiachini, B. ; Basaglia, N. ; Montis, A. ; Lucca, L. F. ; Lombardi, F. ; Ranza, E. ; Vallasciani, M. ; Celentano, A. ; Naldi, A. ; Castellani, G. ; Lamberti, G. ; Lanzillo, B. ; Posteraro, F. ; Logi, F. ; Molteni, F. ; Lanfranchi, M. ; Gramigna, C. ; Bertagnoni, G. ; Dell'Oste, P. ; Tonin, P. ; Iaia, V. ; Posteraro, F. ; Sagliocco, L. ; Beatrici, M. ; Giunta, N. ; Dore, T. ; Galardi, G. ; Sant'Angelo, N. ; Piperno, R. ; Battistini, A. ; Zampolini, M. ; Scarponi, F. ; Sanna, V. ; Biella, A. M. ; Premoselli, S. ; Zaro, F. ; Bernasconi, K. ; Carnovali, M. ; Chierici, S. ; Antenucci, R. ; Salvi, G. P. ; Mazzini, N. ; Ventura, F. ; Lonati, M. C. ; Brianti, R. ; Mammi, P. ; Molinero, G. ; De Tanti, A. ; Bertolino, C. ; Boldrini, P. ; Bargellesi, S. ; Boldrini, P. ; Tessari, A. / Prescribing practice and off-label use of psychotropic medications in post-acute brain injury rehabilitation centres : A cross-sectional survey. In: Brain Injury. 2015 ; Vol. 29, No. 4. pp. 508-516.
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abstract = "Objective: Guidance on pharmacotherapy of neurobehavioural sequelae post-acquired brain injury (ABI) is limited. Clinicians face the choice of prescribing off-label. This survey assesses prescribing practice and off-label use of psychotropic medications in Italian brain injury rehabilitation centres and factors associated with atypical antipsychotics use. Materials and methods: Centres were identified through the roster of the Italian Society for Rehabilitation Medicine. Information was collected through a structured questionnaire. This study calculated the prevalence of centres reporting to use off-label individual medications and unconditional logistic regression Odds Ratio (OR), with 95{\%} confidence interval (95{\%} CI) of atypical antipsychotics use. Results: Psychotropic medications were commonly used. More than 50{\%} of the 35 centres (participation ratio 87.5{\%}) reported to use off-label selected antipsychotics, mostly for agitation (90.5{\%}) and behavioural disturbances (19.0{\%}), and antidepressants, mostly for insomnia (37.5{\%}) and pain (25.0{\%}). Atypical antipsychotic use was directly associated with age",
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T1 - Prescribing practice and off-label use of psychotropic medications in post-acute brain injury rehabilitation centres

T2 - A cross-sectional survey

AU - Pisa, Federica Edith

AU - Cosano, Giorgia

AU - Giangreco, Manuela

AU - Giorgini, Tullio

AU - Biasutti, Emanuele

AU - Barbone, Fabio

AU - Formisano, R.

AU - Buzzi, M. G.

AU - Pistarini, C.

AU - Aiachini, B.

AU - Basaglia, N.

AU - Montis, A.

AU - Lucca, L. F.

AU - Lombardi, F.

AU - Ranza, E.

AU - Vallasciani, M.

AU - Celentano, A.

AU - Naldi, A.

AU - Castellani, G.

AU - Lamberti, G.

AU - Lanzillo, B.

AU - Posteraro, F.

AU - Logi, F.

AU - Molteni, F.

AU - Lanfranchi, M.

AU - Gramigna, C.

AU - Bertagnoni, G.

AU - Dell'Oste, P.

AU - Tonin, P.

AU - Iaia, V.

AU - Posteraro, F.

AU - Sagliocco, L.

AU - Beatrici, M.

AU - Giunta, N.

AU - Dore, T.

AU - Galardi, G.

AU - Sant'Angelo, N.

AU - Piperno, R.

AU - Battistini, A.

AU - Zampolini, M.

AU - Scarponi, F.

AU - Sanna, V.

AU - Biella, A. M.

AU - Premoselli, S.

AU - Zaro, F.

AU - Bernasconi, K.

AU - Carnovali, M.

AU - Chierici, S.

AU - Antenucci, R.

AU - Salvi, G. P.

AU - Mazzini, N.

AU - Ventura, F.

AU - Lonati, M. C.

AU - Brianti, R.

AU - Mammi, P.

AU - Molinero, G.

AU - De Tanti, A.

AU - Bertolino, C.

AU - Boldrini, P.

AU - Bargellesi, S.

AU - Boldrini, P.

AU - Tessari, A.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Objective: Guidance on pharmacotherapy of neurobehavioural sequelae post-acquired brain injury (ABI) is limited. Clinicians face the choice of prescribing off-label. This survey assesses prescribing practice and off-label use of psychotropic medications in Italian brain injury rehabilitation centres and factors associated with atypical antipsychotics use. Materials and methods: Centres were identified through the roster of the Italian Society for Rehabilitation Medicine. Information was collected through a structured questionnaire. This study calculated the prevalence of centres reporting to use off-label individual medications and unconditional logistic regression Odds Ratio (OR), with 95% confidence interval (95% CI) of atypical antipsychotics use. Results: Psychotropic medications were commonly used. More than 50% of the 35 centres (participation ratio 87.5%) reported to use off-label selected antipsychotics, mostly for agitation (90.5%) and behavioural disturbances (19.0%), and antidepressants, mostly for insomnia (37.5%) and pain (25.0%). Atypical antipsychotic use was directly associated with age

AB - Objective: Guidance on pharmacotherapy of neurobehavioural sequelae post-acquired brain injury (ABI) is limited. Clinicians face the choice of prescribing off-label. This survey assesses prescribing practice and off-label use of psychotropic medications in Italian brain injury rehabilitation centres and factors associated with atypical antipsychotics use. Materials and methods: Centres were identified through the roster of the Italian Society for Rehabilitation Medicine. Information was collected through a structured questionnaire. This study calculated the prevalence of centres reporting to use off-label individual medications and unconditional logistic regression Odds Ratio (OR), with 95% confidence interval (95% CI) of atypical antipsychotics use. Results: Psychotropic medications were commonly used. More than 50% of the 35 centres (participation ratio 87.5%) reported to use off-label selected antipsychotics, mostly for agitation (90.5%) and behavioural disturbances (19.0%), and antidepressants, mostly for insomnia (37.5%) and pain (25.0%). Atypical antipsychotic use was directly associated with age

KW - Acquired brain injuries

KW - Antidepressants

KW - Antiepileptic agents

KW - Antipsychotics

KW - Off-label

KW - Pharmacoepidemiology

KW - Prescribing

KW - Prevalence

KW - Psychotropic medications

KW - Survey

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U2 - 10.3109/02699052.2014.992474

DO - 10.3109/02699052.2014.992474

M3 - Article

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JO - Brain Injury

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