Presence of β-arrestin in cellular inclusions in metamphetamine-treated PC12 cells

A. De Blasi, L. Capobianco, L. Iacovelli, P. Lenzi, M. Ferrucci, G. Lazzeri, F. Fornai, A. Picascia

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Cellular inclusions containing ubiquitin and α-synuclein were observed in PC12 cells treated with metamphetamine (MA). To study the possible involvement of β-arrestin in inclusion formation, we treated PC12 cells with MA for different times and analyzed the ubiquitin proteosome pathway (UPP). We found that β-arrestin is ubiquitinated in the MA-treated PC12 cell line. The involvement of β-arrestin in UPP was further supported by electron microscopy and by confocal microscopy, which documented the presence of β-arrestin in these Lewy body-like inclusions. Our experiments reveal an interesting and previously unappreciated connection between β-arrestin and ubiquitination and suggest that β-arrestin could be involved in the development of the inclusion bodies.

Original languageEnglish
Pages (from-to)164-165
Number of pages2
JournalNeurological Sciences
Issue number3
Publication statusPublished - Oct 2003

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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