Presence of ACTH and β-endorphin immunoreactive molecules in the freshwater snail Planorbarius corneus (L.) (Gastropoda, Pulmonata) and their possible role in phagocytosis

Enzo Ottaviani, Felice Petraglia, Giuliano Montagnani, Andrea Cossarizza, Daniela Monti, Claudio Franceschi

Research output: Contribution to journalArticle

Abstract

The presence of ACTH and β-endorphin immunoreactive molecules in the cell-free hemolymph and in the hemocytes of the freshwater snail Planorbarius corneus were demonstrated by immunocytochemistry and RIA tests. Only spreading phagocytic hemocytes were positive, in contrast with other hemocytes devoid of phagocytic activity, i.e., round hemocytes. These data were confirmed by flow cytometry. Another cell type with marked phagocytic activity, i.e., digestive cells of digestive gland, were also positive to anti-ACTH. Corticotropin-releasing factor immunoreactive molecules were found in the cell-free hemolymph and hemocytes, by RIA. Our data suggest that cells with phagocytic activity, the oldest immune response, may represent a suitable model to unravel the tangled web of the common ancestor of the immune and the neuroendocrine systems.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalRegulatory Peptides
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 1 1990

Keywords

  • ACTH
  • Immunoevolution
  • Immunoneuroendocrine system
  • Phagocytosis
  • Planorbarius corneus
  • β-Endorphin

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

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