Abstract
The lymphocyte surface phenotype of lymph nodes from patients with larynx or urinary bladder carcinoma was investigated by using a panel of monoclonal antibodies. The phenotype pattern of lymphocytes from lymph nodes invaded by malignant cells (as assessed by histopathology) was different from that of the cells from noninvaded or normal control nodes. Although the proportion of natural killer cells or macrophages was similar in the 3 groups of lymph nodes, invaded lymph nodes contained a higher proportion of T -cells and a lower B-cell percentage. Furthermore, cells from invaded nodes comprised 15-20% of T3+ T8+ cells that coexpressed the M1 marker and, to some extent, also the Leu 7 marker. A large proportion of cells with multiple markers were activated, as shown by the expression of Tac and HLA-OR antigens. In 2 patients activated T8+ cells expressing also M1 and Leu 7 markers infiltrated the tumor site. The presence of these activated cells both in involved nodes and tumor mass may indicate that they originate in response to cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 637-641 |
| Number of pages | 5 |
| Journal | Journal of the National Cancer Institute |
| Volume | 77 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1986 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Presence of activated t-cells with a T8+ M1+ leu 7+ surface phenotype in invaded lymph nodes from patients with solid tumors. / Cozzolino, Federico; Torcia, Maria; Castigli, Emanuela; Selli, Cesare; Giordani, Rosanna; Carossino, Anna Maria; Squadrelli, Massimo; Cagnoni, Mario; Pistoia, Vito; Ferrarini, Manlio.
In: Journal of the National Cancer Institute, Vol. 77, No. 3, 1986, p. 637-641.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Presence of activated t-cells with a T8+ M1+ leu 7+ surface phenotype in invaded lymph nodes from patients with solid tumors
AU - Cozzolino, Federico
AU - Torcia, Maria
AU - Castigli, Emanuela
AU - Selli, Cesare
AU - Giordani, Rosanna
AU - Carossino, Anna Maria
AU - Squadrelli, Massimo
AU - Cagnoni, Mario
AU - Pistoia, Vito
AU - Ferrarini, Manlio
PY - 1986
Y1 - 1986
N2 - The lymphocyte surface phenotype of lymph nodes from patients with larynx or urinary bladder carcinoma was investigated by using a panel of monoclonal antibodies. The phenotype pattern of lymphocytes from lymph nodes invaded by malignant cells (as assessed by histopathology) was different from that of the cells from noninvaded or normal control nodes. Although the proportion of natural killer cells or macrophages was similar in the 3 groups of lymph nodes, invaded lymph nodes contained a higher proportion of T -cells and a lower B-cell percentage. Furthermore, cells from invaded nodes comprised 15-20% of T3+ T8+ cells that coexpressed the M1 marker and, to some extent, also the Leu 7 marker. A large proportion of cells with multiple markers were activated, as shown by the expression of Tac and HLA-OR antigens. In 2 patients activated T8+ cells expressing also M1 and Leu 7 markers infiltrated the tumor site. The presence of these activated cells both in involved nodes and tumor mass may indicate that they originate in response to cancer.
AB - The lymphocyte surface phenotype of lymph nodes from patients with larynx or urinary bladder carcinoma was investigated by using a panel of monoclonal antibodies. The phenotype pattern of lymphocytes from lymph nodes invaded by malignant cells (as assessed by histopathology) was different from that of the cells from noninvaded or normal control nodes. Although the proportion of natural killer cells or macrophages was similar in the 3 groups of lymph nodes, invaded lymph nodes contained a higher proportion of T -cells and a lower B-cell percentage. Furthermore, cells from invaded nodes comprised 15-20% of T3+ T8+ cells that coexpressed the M1 marker and, to some extent, also the Leu 7 marker. A large proportion of cells with multiple markers were activated, as shown by the expression of Tac and HLA-OR antigens. In 2 patients activated T8+ cells expressing also M1 and Leu 7 markers infiltrated the tumor site. The presence of these activated cells both in involved nodes and tumor mass may indicate that they originate in response to cancer.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022477519&partnerID=8YFLogxK
U2 - 10.1093/jnci/77.3.637
DO - 10.1093/jnci/77.3.637
M3 - Article
C2 - 3091897
AN - SCOPUS:0022477519
VL - 77
SP - 637
EP - 641
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 3
ER -