Presence of HPV in head and neck tumours: High prevalence in tonsillar localization

Aldo Venuti, G. Badaracco, C. Rizzo, B. Mafera, S. Rahimi, M. Vigili

Research output: Contribution to journalArticlepeer-review

Abstract

Human papillomavirus (HPV) seems to be involved in head and neck carcinogenesis. To investigate this association, viral presence and expression were analysed by polymerase chain reaction (PCR)-based methods and correlated to tumour localization, clinical-pathological aspects, and alcohol and tobacco exposure in 65 patients. HPV DNA was found in 16 cases (24.6%); the HPV types detected were: HPV16 (10 cases), HPV 6 (3 cases) HPV 33, 35, and 58 (one case each). The tonsil was the location with the highest HPV positivity (6/8, 75%). This percentage was significantly higher than that found in tumours from any other site (P

Original languageEnglish
Pages (from-to)561-566
Number of pages6
JournalJournal of Experimental and Clinical Cancer Research
Volume23
Issue number4
Publication statusPublished - Dec 2004

Keywords

  • Head and neck tumour
  • HPV
  • Prognosis
  • Risk factor
  • Tonsil

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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