TY - JOUR
T1 - Presence of HPV in head and neck tumours
T2 - High prevalence in tonsillar localization
AU - Venuti, Aldo
AU - Badaracco, G.
AU - Rizzo, C.
AU - Mafera, B.
AU - Rahimi, S.
AU - Vigili, M.
PY - 2004/12
Y1 - 2004/12
N2 - Human papillomavirus (HPV) seems to be involved in head and neck carcinogenesis. To investigate this association, viral presence and expression were analysed by polymerase chain reaction (PCR)-based methods and correlated to tumour localization, clinical-pathological aspects, and alcohol and tobacco exposure in 65 patients. HPV DNA was found in 16 cases (24.6%); the HPV types detected were: HPV16 (10 cases), HPV 6 (3 cases) HPV 33, 35, and 58 (one case each). The tonsil was the location with the highest HPV positivity (6/8, 75%). This percentage was significantly higher than that found in tumours from any other site (P
AB - Human papillomavirus (HPV) seems to be involved in head and neck carcinogenesis. To investigate this association, viral presence and expression were analysed by polymerase chain reaction (PCR)-based methods and correlated to tumour localization, clinical-pathological aspects, and alcohol and tobacco exposure in 65 patients. HPV DNA was found in 16 cases (24.6%); the HPV types detected were: HPV16 (10 cases), HPV 6 (3 cases) HPV 33, 35, and 58 (one case each). The tonsil was the location with the highest HPV positivity (6/8, 75%). This percentage was significantly higher than that found in tumours from any other site (P
KW - Head and neck tumour
KW - HPV
KW - Prognosis
KW - Risk factor
KW - Tonsil
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M3 - Article
C2 - 15743024
AN - SCOPUS:12544259905
VL - 23
SP - 561
EP - 566
JO - Journal of Experimental and Clinical Cancer Research
JF - Journal of Experimental and Clinical Cancer Research
SN - 0392-9078
IS - 4
ER -