Presence of left ventricular contractile reserve predicts midterm response to cardiac resynchronization therapyresults from the LOw dose DObutamine Stress-Echo Test in Cardiac Resynchronization Therapy (LODO-CRT) Trial

Carmine Muto; Maurizio Gasparini; Carlo Peraldo Neja; Saverio Iacopino; Mario Davinelli; Francesco Zanon; Cosimo Dicandia; Giuseppe Distefano; Roberto Donati; Valeria Calvi; Alessandra Denaro; Bernardino Tuccillo

doi:10.1016/j.hrthm.2010.07.036

Presence of left ventricular contractile reserve predicts midterm response to cardiac resynchronization therapyresults from the LOw dose DObutamine Stress-Echo Test in Cardiac Resynchronization Therapy (LODO-CRT) Trial

Carmine Muto, Maurizio Gasparini, Carlo Peraldo Neja, Saverio Iacopino, Mario Davinelli, Francesco Zanon, Cosimo Dicandia, Giuseppe Distefano, Roberto Donati, Valeria Calvi, Alessandra Denaro, Bernardino Tuccillo

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Background Cardiac resynchronization therapy (CRT) is effective in selected patients with heart failure (HF). Nevertheless, the nonresponder rate remains high. The low-dose dobutamine stress-echo (DSE) test detects the presence of left ventricular (LV) contractile reserve (LVCR) in HF patients of any etiology and may be useful in predicting response to resynchronization. Objective The purpose of this study was to present the results of the LODO-CRT trial, which evaluated whether LVCR presence at baseline increases the chances of response to CRT. Methods LODO-CRT is a multicenter prospective study that enrolled CRT candidates according to guidelines. LVCR presence was defined as an LV ejection fraction increase >5 units during DSE test. CRT response is assessed at 6-month follow-up as an LV end-systolic volume reduction

Original language	English
Pages (from-to)	1600-1605
Number of pages	6
Journal	Heart Rhythm
Volume	7
Issue number	11
DOIs	https://doi.org/10.1016/j.hrthm.2010.07.036
Publication status	Published - Nov 2010

Keywords

Cardiac resynchronization therapy
Heart failure
Stress echocardiography

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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Muto, C., Gasparini, M., Neja, C. P., Iacopino, S., Davinelli, M., Zanon, F., Dicandia, C., Distefano, G., Donati, R., Calvi, V., Denaro, A., & Tuccillo, B. (2010). Presence of left ventricular contractile reserve predicts midterm response to cardiac resynchronization therapyresults from the LOw dose DObutamine Stress-Echo Test in Cardiac Resynchronization Therapy (LODO-CRT) Trial. Heart Rhythm, 7(11), 1600-1605. https://doi.org/10.1016/j.hrthm.2010.07.036

Presence of left ventricular contractile reserve predicts midterm response to cardiac resynchronization therapyresults from the LOw dose DObutamine Stress-Echo Test in Cardiac Resynchronization Therapy (LODO-CRT) Trial. / Muto, Carmine; Gasparini, Maurizio; Neja, Carlo Peraldo; Iacopino, Saverio; Davinelli, Mario; Zanon, Francesco; Dicandia, Cosimo; Distefano, Giuseppe; Donati, Roberto; Calvi, Valeria; Denaro, Alessandra; Tuccillo, Bernardino.

In: Heart Rhythm, Vol. 7, No. 11, 11.2010, p. 1600-1605.

Research output: Contribution to journal › Article › peer-review

Muto, C, Gasparini, M, Neja, CP, Iacopino, S, Davinelli, M, Zanon, F, Dicandia, C, Distefano, G, Donati, R, Calvi, V, Denaro, A & Tuccillo, B 2010, 'Presence of left ventricular contractile reserve predicts midterm response to cardiac resynchronization therapyresults from the LOw dose DObutamine Stress-Echo Test in Cardiac Resynchronization Therapy (LODO-CRT) Trial', Heart Rhythm, vol. 7, no. 11, pp. 1600-1605. https://doi.org/10.1016/j.hrthm.2010.07.036

Muto C, Gasparini M, Neja CP, Iacopino S, Davinelli M, Zanon F et al. Presence of left ventricular contractile reserve predicts midterm response to cardiac resynchronization therapyresults from the LOw dose DObutamine Stress-Echo Test in Cardiac Resynchronization Therapy (LODO-CRT) Trial. Heart Rhythm. 2010 Nov;7(11):1600-1605. https://doi.org/10.1016/j.hrthm.2010.07.036

Muto, Carmine ; Gasparini, Maurizio ; Neja, Carlo Peraldo ; Iacopino, Saverio ; Davinelli, Mario ; Zanon, Francesco ; Dicandia, Cosimo ; Distefano, Giuseppe ; Donati, Roberto ; Calvi, Valeria ; Denaro, Alessandra ; Tuccillo, Bernardino. / Presence of left ventricular contractile reserve predicts midterm response to cardiac resynchronization therapyresults from the LOw dose DObutamine Stress-Echo Test in Cardiac Resynchronization Therapy (LODO-CRT) Trial. In: Heart Rhythm. 2010 ; Vol. 7, No. 11. pp. 1600-1605.

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abstract = "Background Cardiac resynchronization therapy (CRT) is effective in selected patients with heart failure (HF). Nevertheless, the nonresponder rate remains high. The low-dose dobutamine stress-echo (DSE) test detects the presence of left ventricular (LV) contractile reserve (LVCR) in HF patients of any etiology and may be useful in predicting response to resynchronization. Objective The purpose of this study was to present the results of the LODO-CRT trial, which evaluated whether LVCR presence at baseline increases the chances of response to CRT. Methods LODO-CRT is a multicenter prospective study that enrolled CRT candidates according to guidelines. LVCR presence was defined as an LV ejection fraction increase >5 units during DSE test. CRT response is assessed at 6-month follow-up as an LV end-systolic volume reduction ",

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AU - Gasparini, Maurizio

AU - Neja, Carlo Peraldo

AU - Iacopino, Saverio

AU - Davinelli, Mario

AU - Zanon, Francesco

AU - Dicandia, Cosimo

AU - Distefano, Giuseppe

AU - Donati, Roberto

AU - Calvi, Valeria

AU - Denaro, Alessandra

AU - Tuccillo, Bernardino

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AB - Background Cardiac resynchronization therapy (CRT) is effective in selected patients with heart failure (HF). Nevertheless, the nonresponder rate remains high. The low-dose dobutamine stress-echo (DSE) test detects the presence of left ventricular (LV) contractile reserve (LVCR) in HF patients of any etiology and may be useful in predicting response to resynchronization. Objective The purpose of this study was to present the results of the LODO-CRT trial, which evaluated whether LVCR presence at baseline increases the chances of response to CRT. Methods LODO-CRT is a multicenter prospective study that enrolled CRT candidates according to guidelines. LVCR presence was defined as an LV ejection fraction increase >5 units during DSE test. CRT response is assessed at 6-month follow-up as an LV end-systolic volume reduction

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KW - Heart failure

KW - Stress echocardiography

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