TY - JOUR
T1 - Presence of left ventricular contractile reserve predicts midterm response to cardiac resynchronization therapyresults from the LOw dose DObutamine Stress-Echo Test in Cardiac Resynchronization Therapy (LODO-CRT) Trial
AU - Muto, Carmine
AU - Gasparini, Maurizio
AU - Neja, Carlo Peraldo
AU - Iacopino, Saverio
AU - Davinelli, Mario
AU - Zanon, Francesco
AU - Dicandia, Cosimo
AU - Distefano, Giuseppe
AU - Donati, Roberto
AU - Calvi, Valeria
AU - Denaro, Alessandra
AU - Tuccillo, Bernardino
PY - 2010/11
Y1 - 2010/11
N2 - Background Cardiac resynchronization therapy (CRT) is effective in selected patients with heart failure (HF). Nevertheless, the nonresponder rate remains high. The low-dose dobutamine stress-echo (DSE) test detects the presence of left ventricular (LV) contractile reserve (LVCR) in HF patients of any etiology and may be useful in predicting response to resynchronization. Objective The purpose of this study was to present the results of the LODO-CRT trial, which evaluated whether LVCR presence at baseline increases the chances of response to CRT. Methods LODO-CRT is a multicenter prospective study that enrolled CRT candidates according to guidelines. LVCR presence was defined as an LV ejection fraction increase >5 units during DSE test. CRT response is assessed at 6-month follow-up as an LV end-systolic volume reduction
AB - Background Cardiac resynchronization therapy (CRT) is effective in selected patients with heart failure (HF). Nevertheless, the nonresponder rate remains high. The low-dose dobutamine stress-echo (DSE) test detects the presence of left ventricular (LV) contractile reserve (LVCR) in HF patients of any etiology and may be useful in predicting response to resynchronization. Objective The purpose of this study was to present the results of the LODO-CRT trial, which evaluated whether LVCR presence at baseline increases the chances of response to CRT. Methods LODO-CRT is a multicenter prospective study that enrolled CRT candidates according to guidelines. LVCR presence was defined as an LV ejection fraction increase >5 units during DSE test. CRT response is assessed at 6-month follow-up as an LV end-systolic volume reduction
KW - Cardiac resynchronization therapy
KW - Heart failure
KW - Stress echocardiography
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U2 - 10.1016/j.hrthm.2010.07.036
DO - 10.1016/j.hrthm.2010.07.036
M3 - Article
C2 - 20691283
AN - SCOPUS:78049454499
VL - 7
SP - 1600
EP - 1605
JO - Heart Rhythm
JF - Heart Rhythm
SN - 1547-5271
IS - 11
ER -