Presence of N-methyl-D-aspartate-like and kainate-like and kainate-like activities in bovine brain

Alberto Luini, Ora Goldberg, Vivian I. Teichberg

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Searching for the natural ligands interacting with brain excitatory amino acid receptors, we have isolated from cow brain a low-Mr ampholyte fraction containing molecules with excitatory properties similar to those of N-methyl-D-aspartate and kainate, which cannot be accounted for by any of the known brain excitants. This finding supports the hypothesis of the existence of excitatory neurotransmitters other than L-glutamate and L-aspartate.

Original languageEnglish
Pages (from-to)153-157
Number of pages5
JournalFEBS Letters
Volume161
Issue number1
DOIs
Publication statusPublished - Sep 5 1983

Fingerprint

Kainic Acid
N-Methylaspartate
Brain
Glutamate Receptors
Aspartic Acid
Neurotransmitter Agents
Glutamic Acid
Buffers
Ligands
Molecules

Keywords

  • Brain endogenous ligand
  • Excitatory amino acid
  • Putative excitatory neurotransmitter
  • Receptor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Presence of N-methyl-D-aspartate-like and kainate-like and kainate-like activities in bovine brain. / Luini, Alberto; Goldberg, Ora; Teichberg, Vivian I.

In: FEBS Letters, Vol. 161, No. 1, 05.09.1983, p. 153-157.

Research output: Contribution to journalArticle

Luini, Alberto ; Goldberg, Ora ; Teichberg, Vivian I. / Presence of N-methyl-D-aspartate-like and kainate-like and kainate-like activities in bovine brain. In: FEBS Letters. 1983 ; Vol. 161, No. 1. pp. 153-157.
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