Abstract
Searching for the natural ligands interacting with brain excitatory amino acid receptors, we have isolated from cow brain a low-Mr ampholyte fraction containing molecules with excitatory properties similar to those of N-methyl-D-aspartate and kainate, which cannot be accounted for by any of the known brain excitants. This finding supports the hypothesis of the existence of excitatory neurotransmitters other than L-glutamate and L-aspartate.
Original language | English |
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Pages (from-to) | 153-157 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 161 |
Issue number | 1 |
DOIs | |
Publication status | Published - Sep 5 1983 |
Keywords
- Brain endogenous ligand
- Excitatory amino acid
- Putative excitatory neurotransmitter
- Receptor
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology