Abstract
Searching for the natural ligands interacting with brain excitatory amino acid receptors, we have isolated from cow brain a low-Mr ampholyte fraction containing molecules with excitatory properties similar to those of N-methyl-D-aspartate and kainate, which cannot be accounted for by any of the known brain excitants. This finding supports the hypothesis of the existence of excitatory neurotransmitters other than L-glutamate and L-aspartate.
| Original language | English |
|---|---|
| Pages (from-to) | 153-157 |
| Number of pages | 5 |
| Journal | FEBS Letters |
| Volume | 161 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Sep 5 1983 |
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Keywords
- Brain endogenous ligand
- Excitatory amino acid
- Putative excitatory neurotransmitter
- Receptor
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Presence of N-methyl-D-aspartate-like and kainate-like and kainate-like activities in bovine brain. / Luini, Alberto; Goldberg, Ora; Teichberg, Vivian I.
In: FEBS Letters, Vol. 161, No. 1, 05.09.1983, p. 153-157.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Presence of N-methyl-D-aspartate-like and kainate-like and kainate-like activities in bovine brain
AU - Luini, Alberto
AU - Goldberg, Ora
AU - Teichberg, Vivian I.
PY - 1983/9/5
Y1 - 1983/9/5
N2 - Searching for the natural ligands interacting with brain excitatory amino acid receptors, we have isolated from cow brain a low-Mr ampholyte fraction containing molecules with excitatory properties similar to those of N-methyl-D-aspartate and kainate, which cannot be accounted for by any of the known brain excitants. This finding supports the hypothesis of the existence of excitatory neurotransmitters other than L-glutamate and L-aspartate.
AB - Searching for the natural ligands interacting with brain excitatory amino acid receptors, we have isolated from cow brain a low-Mr ampholyte fraction containing molecules with excitatory properties similar to those of N-methyl-D-aspartate and kainate, which cannot be accounted for by any of the known brain excitants. This finding supports the hypothesis of the existence of excitatory neurotransmitters other than L-glutamate and L-aspartate.
KW - Brain endogenous ligand
KW - Excitatory amino acid
KW - Putative excitatory neurotransmitter
KW - Receptor
UR - http://www.scopus.com/inward/record.url?scp=0020564945&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020564945&partnerID=8YFLogxK
U2 - 10.1016/0014-5793(83)80750-9
DO - 10.1016/0014-5793(83)80750-9
M3 - Article
C2 - 6136419
AN - SCOPUS:0020564945
VL - 161
SP - 153
EP - 157
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 1
ER -