Presence of N-methyl-D-aspartate-like and kainate-like and kainate-like activities in bovine brain

Alberto Luini, Ora Goldberg, Vivian I. Teichberg

Research output: Contribution to journalArticle

Abstract

Searching for the natural ligands interacting with brain excitatory amino acid receptors, we have isolated from cow brain a low-Mr ampholyte fraction containing molecules with excitatory properties similar to those of N-methyl-D-aspartate and kainate, which cannot be accounted for by any of the known brain excitants. This finding supports the hypothesis of the existence of excitatory neurotransmitters other than L-glutamate and L-aspartate.

Original languageEnglish
Pages (from-to)153-157
Number of pages5
JournalFEBS Letters
Volume161
Issue number1
DOIs
Publication statusPublished - Sep 5 1983

Keywords

  • Brain endogenous ligand
  • Excitatory amino acid
  • Putative excitatory neurotransmitter
  • Receptor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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