Abstract
Searching for the natural ligands interacting with brain excitatory amino acid receptors, we have isolated from cow brain a low-Mr ampholyte fraction containing molecules with excitatory properties similar to those of N-methyl-D-aspartate and kainate, which cannot be accounted for by any of the known brain excitants. This finding supports the hypothesis of the existence of excitatory neurotransmitters other than L-glutamate and L-aspartate.
| Original language | English |
|---|---|
| Pages (from-to) | 153-157 |
| Number of pages | 5 |
| Journal | FEBS Letters |
| Volume | 161 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Sep 5 1983 |
Keywords
- Brain endogenous ligand
- Excitatory amino acid
- Putative excitatory neurotransmitter
- Receptor
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
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Luini, A., Goldberg, O., & Teichberg, V. I. (1983). Presence of N-methyl-D-aspartate-like and kainate-like and kainate-like activities in bovine brain. FEBS Letters, 161(1), 153-157. https://doi.org/10.1016/0014-5793(83)80750-9