Presence of nerve growth factor and NGF-receptors in human Schwannoma cells

L. Aloe, E. Vigneti, R. Cavalieri, B. Didona, L. Bracci-Laudiero, C. Mazzanti, G. Papa, R. Stasi, R. Levi-Montalcini

Research output: Contribution to journalArticle

Abstract

Evidence is presented which shows that a Schwannoma removed from a 70-year-old woman contained a high level of NGF and also expressed NGF-r in addition to two other specific Schwann cell markers, S-100 and GFAP. A cell line expressing NGF and NGF-receptors was isolated from this neoplastic tissue. It is suggested that this cell line might provide a useful model for studying mechanisms which regulate NGF and NGF-r.

Original languageEnglish
Pages (from-to)309-313
Number of pages5
JournalClinical Chemistry and Enzymology Communications
Volume5
Issue number4-6
Publication statusPublished - 1993

Fingerprint

Nerve Growth Factor Receptors
Neurilemmoma
Nerve Growth Factor
Cells
Cell Line
Schwann Cells
Tissue

Keywords

  • Nerve growth factor (NGF)
  • NGF-receptors
  • S-100
  • Schwannoma

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Aloe, L., Vigneti, E., Cavalieri, R., Didona, B., Bracci-Laudiero, L., Mazzanti, C., ... Levi-Montalcini, R. (1993). Presence of nerve growth factor and NGF-receptors in human Schwannoma cells. Clinical Chemistry and Enzymology Communications, 5(4-6), 309-313.

Presence of nerve growth factor and NGF-receptors in human Schwannoma cells. / Aloe, L.; Vigneti, E.; Cavalieri, R.; Didona, B.; Bracci-Laudiero, L.; Mazzanti, C.; Papa, G.; Stasi, R.; Levi-Montalcini, R.

In: Clinical Chemistry and Enzymology Communications, Vol. 5, No. 4-6, 1993, p. 309-313.

Research output: Contribution to journalArticle

Aloe, L, Vigneti, E, Cavalieri, R, Didona, B, Bracci-Laudiero, L, Mazzanti, C, Papa, G, Stasi, R & Levi-Montalcini, R 1993, 'Presence of nerve growth factor and NGF-receptors in human Schwannoma cells', Clinical Chemistry and Enzymology Communications, vol. 5, no. 4-6, pp. 309-313.
Aloe, L. ; Vigneti, E. ; Cavalieri, R. ; Didona, B. ; Bracci-Laudiero, L. ; Mazzanti, C. ; Papa, G. ; Stasi, R. ; Levi-Montalcini, R. / Presence of nerve growth factor and NGF-receptors in human Schwannoma cells. In: Clinical Chemistry and Enzymology Communications. 1993 ; Vol. 5, No. 4-6. pp. 309-313.
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AU - Vigneti, E.

AU - Cavalieri, R.

AU - Didona, B.

AU - Bracci-Laudiero, L.

AU - Mazzanti, C.

AU - Papa, G.

AU - Stasi, R.

AU - Levi-Montalcini, R.

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