Presence of residues and metabolites of pharmaceuticals in environmental compartments, food commodities and workplaces: A review spanning the three-year period 2014–2016

Paola Bottoni, Sergio Caroli

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Residues and metabolites of pharmaceuticals can pollute environmental compartments, food commodities and workplaces, thus posing a serious threat to human health and environmental integrity. Needless to say, this challenge is increasingly attracting the attention of the international scientific community, the decision makers and the layman. Much concern has been expressed over the past few years over the deleterious consequences of the discharge of medicinal products, often as unused or expired products, into the various environmental compartments, to say nothing of their occurrence in foodstuff and feedstuff and of their undue presence in the workplace. This widespread presence inescapably raises a number of questions among which of prime importance is the reliable quantification of such residues and metabolites in the various media in order to assess whether and to what extent they can endanger biota and humans. This work summarizes the key findings of an overview of the scientific literature in this field approximately over the past three years (2014–2016) with particular regard to the most fit-for-purpose analytical approaches currently resorted to for the detection, identification and quantification of residues of medicinal products in the most diverse matrices along with the assessment of their noxious potential. A total of almost 1000 papers, reports and other publicly available documents published in the said period were scanned.

Original languageEnglish
Pages (from-to)2-24
Number of pages23
JournalMicrochemical Journal
Volume136
DOIs
Publication statusPublished - Jan 1 2018
Externally publishedYes

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Metabolites
Pharmaceutical Preparations
Health
Biota

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

Cite this

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abstract = "Residues and metabolites of pharmaceuticals can pollute environmental compartments, food commodities and workplaces, thus posing a serious threat to human health and environmental integrity. Needless to say, this challenge is increasingly attracting the attention of the international scientific community, the decision makers and the layman. Much concern has been expressed over the past few years over the deleterious consequences of the discharge of medicinal products, often as unused or expired products, into the various environmental compartments, to say nothing of their occurrence in foodstuff and feedstuff and of their undue presence in the workplace. This widespread presence inescapably raises a number of questions among which of prime importance is the reliable quantification of such residues and metabolites in the various media in order to assess whether and to what extent they can endanger biota and humans. This work summarizes the key findings of an overview of the scientific literature in this field approximately over the past three years (2014–2016) with particular regard to the most fit-for-purpose analytical approaches currently resorted to for the detection, identification and quantification of residues of medicinal products in the most diverse matrices along with the assessment of their noxious potential. A total of almost 1000 papers, reports and other publicly available documents published in the said period were scanned.",
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