Presence of T-cell subset abnormalities in newly diagnosed cases of multiple sclerosis and relationship with short-term clinical activity

M. Eoli, M. Ferrarini, A. Dufour, S. Heltaj, L. Bevilacqua, G. Comi, V. Cosi, G. Filippini, V. Martinelli, C. Milanese, L. LaMantia, A. Salmaggi

Research output: Contribution to journalArticle

Abstract

Abnormalities of T-cell subsets in patients with multiple sclerosis are well known; in order to assess whether immunological abnormalities are relevant in the pathogenesis of the disease after its clinical onset, peripheral blood lymphocyte subsets (CD3+, CD4+, CD4+ CD45RA+, CD4+CD45RA-, CD8+, CD8+CD57+, CD57+, CD25+) were analysed serially in 25 patients at the first clinical episode suggestive of inflammatory demyelinating disease and in an equal number of age- and sex-matched controls. During the follow-up period (12-18 months, mean 14) 6 of 25 patients presented new relapses: in this subgroup of patients, significant changes in CD4+ ratio (% CD4+CD45RA-/%CD4+CD45RA-) were detected in comparison both with healthy controls and with clinically stable patients. Patients clinically stable at follow-up did not display immunological abnormalities, regardless of the presence or absence of cerebrospinal fluid and/or magnetic resonance imaging alterations consistent with multiple sclerosis. These findings suggest a possible prognostic role of early T-cell subset imbalance in multiple sclerosis.

Original languageEnglish
Pages (from-to)79-82
Number of pages4
JournalJournal of Neurology
Volume240
Issue number2
DOIs
Publication statusPublished - Feb 1993

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Keywords

  • Multiple sclerosis
  • T-cell subsets

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Eoli, M., Ferrarini, M., Dufour, A., Heltaj, S., Bevilacqua, L., Comi, G., Cosi, V., Filippini, G., Martinelli, V., Milanese, C., LaMantia, L., & Salmaggi, A. (1993). Presence of T-cell subset abnormalities in newly diagnosed cases of multiple sclerosis and relationship with short-term clinical activity. Journal of Neurology, 240(2), 79-82. https://doi.org/10.1007/BF00858721