Presence of T-cell subset abnormalities in newly diagnosed cases of multiple sclerosis and relationship with short-term clinical activity

M. Eoli, M. Ferrarini, A. Dufour, S. Heltaj, L. Bevilacqua, G. Comi, V. Cosi, G. Filippini, V. Martinelli, C. Milanese, L. LaMantia, A. Salmaggi

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Abstract

Abnormalities of T-cell subsets in patients with multiple sclerosis are well known; in order to assess whether immunological abnormalities are relevant in the pathogenesis of the disease after its clinical onset, peripheral blood lymphocyte subsets (CD3+, CD4+, CD4+ CD45RA+, CD4+CD45RA-, CD8+, CD8+CD57+, CD57+, CD25+) were analysed serially in 25 patients at the first clinical episode suggestive of inflammatory demyelinating disease and in an equal number of age- and sex-matched controls. During the follow-up period (12-18 months, mean 14) 6 of 25 patients presented new relapses: in this subgroup of patients, significant changes in CD4+ ratio (% CD4+CD45RA-/%CD4+CD45RA-) were detected in comparison both with healthy controls and with clinically stable patients. Patients clinically stable at follow-up did not display immunological abnormalities, regardless of the presence or absence of cerebrospinal fluid and/or magnetic resonance imaging alterations consistent with multiple sclerosis. These findings suggest a possible prognostic role of early T-cell subset imbalance in multiple sclerosis.

Original languageEnglish
Pages (from-to)79-82
Number of pages4
JournalJournal of Neurology
Volume240
Issue number2
DOIs
Publication statusPublished - Feb 1993

Fingerprint

T-Lymphocyte Subsets
Multiple Sclerosis
Lymphocyte Subsets
Demyelinating Diseases
Cerebrospinal Fluid
Magnetic Resonance Imaging
Recurrence

Keywords

  • Multiple sclerosis
  • T-cell subsets

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Presence of T-cell subset abnormalities in newly diagnosed cases of multiple sclerosis and relationship with short-term clinical activity. / Eoli, M.; Ferrarini, M.; Dufour, A.; Heltaj, S.; Bevilacqua, L.; Comi, G.; Cosi, V.; Filippini, G.; Martinelli, V.; Milanese, C.; LaMantia, L.; Salmaggi, A.

In: Journal of Neurology, Vol. 240, No. 2, 02.1993, p. 79-82.

Research output: Contribution to journalArticle

Eoli, M, Ferrarini, M, Dufour, A, Heltaj, S, Bevilacqua, L, Comi, G, Cosi, V, Filippini, G, Martinelli, V, Milanese, C, LaMantia, L & Salmaggi, A 1993, 'Presence of T-cell subset abnormalities in newly diagnosed cases of multiple sclerosis and relationship with short-term clinical activity', Journal of Neurology, vol. 240, no. 2, pp. 79-82. https://doi.org/10.1007/BF00858721
Eoli, M. ; Ferrarini, M. ; Dufour, A. ; Heltaj, S. ; Bevilacqua, L. ; Comi, G. ; Cosi, V. ; Filippini, G. ; Martinelli, V. ; Milanese, C. ; LaMantia, L. ; Salmaggi, A. / Presence of T-cell subset abnormalities in newly diagnosed cases of multiple sclerosis and relationship with short-term clinical activity. In: Journal of Neurology. 1993 ; Vol. 240, No. 2. pp. 79-82.
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