TY - JOUR
T1 - Presence of the bcl-2 protein and apoptosis in non-Hodgkin lymphomas with diffuse growth pattern
AU - Leoncini, L.
AU - Del Vecchio, M. T.
AU - Spina, D.
AU - Megha, T.
AU - Barbini, P.
AU - Sabattini, E.
AU - Pileri, S.
AU - Tosi, P.
AU - Kraft, R.
AU - Laissue, J. A.
AU - Cottier, H.
PY - 1995
Y1 - 1995
N2 - In an attempt to further clarify the role of the apoptosis-counteracting protein bcl-2, non-Hodgkin lymphomas (NHL, n = 170) were examined immunohistochemically, across the boundaries of histologic classification, for the presence of this oncoprotein, in comparison with apoptotic indices (A1) and percentages of Ki-67+ cells (growth fraction). The results of this retrospective study revealed a highly significant inverse relationship ('mirror image') between the proportion of bcl-2+ cells and the A1 per case. Both these parameters, although variable, clearly distinguished low- from high-grade-malignancy lymphomas according to the Kiel classification. Cluster analysis detected 2 separate groups of high-grade NHL, one with rather high A1 and low percentages of bcl-2+ cells, comprising most anaplastic large-cell lymphomas, the other group with reverse characteristics. We found no correlation between the percentage of bcl-2+ cells per case and overall survival.
AB - In an attempt to further clarify the role of the apoptosis-counteracting protein bcl-2, non-Hodgkin lymphomas (NHL, n = 170) were examined immunohistochemically, across the boundaries of histologic classification, for the presence of this oncoprotein, in comparison with apoptotic indices (A1) and percentages of Ki-67+ cells (growth fraction). The results of this retrospective study revealed a highly significant inverse relationship ('mirror image') between the proportion of bcl-2+ cells and the A1 per case. Both these parameters, although variable, clearly distinguished low- from high-grade-malignancy lymphomas according to the Kiel classification. Cluster analysis detected 2 separate groups of high-grade NHL, one with rather high A1 and low percentages of bcl-2+ cells, comprising most anaplastic large-cell lymphomas, the other group with reverse characteristics. We found no correlation between the percentage of bcl-2+ cells per case and overall survival.
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U2 - 10.1002/ijc.2910610614
DO - 10.1002/ijc.2910610614
M3 - Article
C2 - 7790118
AN - SCOPUS:0029034187
VL - 61
SP - 826
EP - 831
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 6
ER -