Presenilin 2 is secreted in mouse primary neurons: A release enhanced by apoptosis

Research output: Contribution to journalArticlepeer-review

Abstract

Presenilin 1 (PS1) and presenilin 2 (PS2) are homologous transmembrane proteins genetically associated with Alzheimer disease. As previously reported by our group for PS1, here we demonstrated that, in mouse primary neurons and microglial cells, PS2 C-terminal fragment (CTF) is released by shedding into the extracellular compartment as a soluble form and that this release is 4.07-fold increased during apoptosis. When compared with PS1, PS2 seems to be more susceptible to apoptosis since its secretion is increased 2.8-fold more than PS1. During apoptosis either proteins were colocalized especially within shedded vesicles. The present study suggest an active role for the presenilins CTF on putative target cells.

Original languageEnglish
Pages (from-to)350-353
Number of pages4
JournalMechanisms of Ageing and Development
Volume128
Issue number4
DOIs
Publication statusPublished - Apr 2007

Keywords

  • Alzheimer disease
  • Apoptosis
  • Confocal imaging
  • Mouse primary neurones
  • Presenilin
  • Shedding

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

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