Present and future of influenza prevention in pediatrics

Nicola Principi, Susanna Esposito, Paola Marchisio

Research output: Contribution to journalArticlepeer-review


Introduction: Pediatric influenza not only leads to significant rates of morbidity and an increased risk of hospitalisation, it can also have a substantial socio-economic impact because children shed larger amounts of viruses over longer periods than adults. This makes adequate prevention desirable, and the best means of reducing the incidence and risks of infection in children is influenza vaccination. Areas covered: The main aim of this review is to analyse the characteristics of new means of influenza prevention and identify which may be important in pediatrics. An updated overview of influenza vaccines is provided, concentrating on strategies of inducing immunogenicity and facilitating the administration of both old and new vaccines. Expert opinion: The currently available data clearly indicate that influenza in children is much less optimally prevented than other vaccine-preventable diseases. A number of different approaches seem to be promising in adults, but there is an urgent need for new strategies when using old vaccines in children or testing new vaccines in pediatric trials.

Original languageEnglish
Pages (from-to)641-653
Number of pages13
JournalExpert Opinion on Biological Therapy
Issue number5
Publication statusPublished - May 2011


  • Adjuvants
  • children
  • influenza
  • influenza vaccines
  • prevention
  • vaccination

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry
  • Drug Discovery


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