Abstract
Both in clinical practice and in drug trials, combination treatment of hypertension plays a fundamental role. This article reviews the features that make combined therapy with two drugs valuable, i.e., additive antihypertensive efficacy, different mechanisms of action, and reciprocal side-effect minimization. Also examined are the advantages and disadvantages of a fixed combination, emphasizing that a major advantage is simplification of the treatment schedule. This is clinically relevant because complexity of treatment negatively affects patient compliance, which in hypertensive patients is poor, leading to poor long-term blood pressure control in the hypertensive fraction of the population.
Original language | English |
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Journal | Journal of Cardiovascular Pharmacology |
Volume | 31 |
Issue number | SUPPL. 2 |
Publication status | Published - 1998 |
Keywords
- Combination therapy
- Hypertension
- Mechanisms of action
- Patient compliance
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Pharmacology