Abstract
Both in clinical practice and in drug trials, combination treatment of hypertension plays a fundamental role. This article reviews the features that make combined therapy with two drugs valuable, i.e., additive antihypertensive efficacy, different mechanisms of action, and reciprocal side-effect minimization. Also examined are the advantages and disadvantages of a fixed combination, emphasizing that a major advantage is simplification of the treatment schedule. This is clinically relevant because complexity of treatment negatively affects patient compliance, which in hypertensive patients is poor, leading to poor long-term blood pressure control in the hypertensive fraction of the population.
| Original language | English |
|---|---|
| Journal | Journal of Cardiovascular Pharmacology |
| Volume | 31 |
| Issue number | SUPPL. 2 |
| Publication status | Published - 1998 |
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Keywords
- Combination therapy
- Hypertension
- Mechanisms of action
- Patient compliance
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Pharmacology
Cite this
Present and future role of combination treatment in hypertension. / Mancia, Giuseppe; Failla, Monica; Grappiolo, Alessandra; Giannattasio, Cristina.
In: Journal of Cardiovascular Pharmacology, Vol. 31, No. SUPPL. 2, 1998.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Present and future role of combination treatment in hypertension
AU - Mancia, Giuseppe
AU - Failla, Monica
AU - Grappiolo, Alessandra
AU - Giannattasio, Cristina
PY - 1998
Y1 - 1998
N2 - Both in clinical practice and in drug trials, combination treatment of hypertension plays a fundamental role. This article reviews the features that make combined therapy with two drugs valuable, i.e., additive antihypertensive efficacy, different mechanisms of action, and reciprocal side-effect minimization. Also examined are the advantages and disadvantages of a fixed combination, emphasizing that a major advantage is simplification of the treatment schedule. This is clinically relevant because complexity of treatment negatively affects patient compliance, which in hypertensive patients is poor, leading to poor long-term blood pressure control in the hypertensive fraction of the population.
AB - Both in clinical practice and in drug trials, combination treatment of hypertension plays a fundamental role. This article reviews the features that make combined therapy with two drugs valuable, i.e., additive antihypertensive efficacy, different mechanisms of action, and reciprocal side-effect minimization. Also examined are the advantages and disadvantages of a fixed combination, emphasizing that a major advantage is simplification of the treatment schedule. This is clinically relevant because complexity of treatment negatively affects patient compliance, which in hypertensive patients is poor, leading to poor long-term blood pressure control in the hypertensive fraction of the population.
KW - Combination therapy
KW - Hypertension
KW - Mechanisms of action
KW - Patient compliance
UR - http://www.scopus.com/inward/record.url?scp=0031627211&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031627211&partnerID=8YFLogxK
M3 - Article
C2 - 9605601
AN - SCOPUS:0031627211
VL - 31
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
SN - 0160-2446
IS - SUPPL. 2
ER -