Present and future role of combination treatment in hypertension

Giuseppe Mancia, Monica Failla, Alessandra Grappiolo, Cristina Giannattasio

Research output: Contribution to journalArticle

Abstract

Both in clinical practice and in drug trials, combination treatment of hypertension plays a fundamental role. This article reviews the features that make combined therapy with two drugs valuable, i.e., additive antihypertensive efficacy, different mechanisms of action, and reciprocal side-effect minimization. Also examined are the advantages and disadvantages of a fixed combination, emphasizing that a major advantage is simplification of the treatment schedule. This is clinically relevant because complexity of treatment negatively affects patient compliance, which in hypertensive patients is poor, leading to poor long-term blood pressure control in the hypertensive fraction of the population.

Original languageEnglish
JournalJournal of Cardiovascular Pharmacology
Volume31
Issue numberSUPPL. 2
Publication statusPublished - 1998

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Hypertension
Drug Combinations
Therapeutics
Patient Compliance
Antihypertensive Agents
Appointments and Schedules
Blood Pressure
Pharmaceutical Preparations
Population

Keywords

  • Combination therapy
  • Hypertension
  • Mechanisms of action
  • Patient compliance

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Mancia, G., Failla, M., Grappiolo, A., & Giannattasio, C. (1998). Present and future role of combination treatment in hypertension. Journal of Cardiovascular Pharmacology, 31(SUPPL. 2).

Present and future role of combination treatment in hypertension. / Mancia, Giuseppe; Failla, Monica; Grappiolo, Alessandra; Giannattasio, Cristina.

In: Journal of Cardiovascular Pharmacology, Vol. 31, No. SUPPL. 2, 1998.

Research output: Contribution to journalArticle

Mancia, G, Failla, M, Grappiolo, A & Giannattasio, C 1998, 'Present and future role of combination treatment in hypertension', Journal of Cardiovascular Pharmacology, vol. 31, no. SUPPL. 2.
Mancia G, Failla M, Grappiolo A, Giannattasio C. Present and future role of combination treatment in hypertension. Journal of Cardiovascular Pharmacology. 1998;31(SUPPL. 2).
Mancia, Giuseppe ; Failla, Monica ; Grappiolo, Alessandra ; Giannattasio, Cristina. / Present and future role of combination treatment in hypertension. In: Journal of Cardiovascular Pharmacology. 1998 ; Vol. 31, No. SUPPL. 2.
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