Present and future role of combination treatment in hypertension

Giuseppe Mancia, Monica Failla, Alessandra Grappiolo, Cristina Giannattasio

Research output: Contribution to journalArticlepeer-review


Both in clinical practice and in drug trials, combination treatment of hypertension plays a fundamental role. This article reviews the features that make combined therapy with two drugs valuable, i.e., additive antihypertensive efficacy, different mechanisms of action, and reciprocal side-effect minimization. Also examined are the advantages and disadvantages of a fixed combination, emphasizing that a major advantage is simplification of the treatment schedule. This is clinically relevant because complexity of treatment negatively affects patient compliance, which in hypertensive patients is poor, leading to poor long-term blood pressure control in the hypertensive fraction of the population.

Original languageEnglish
JournalJournal of Cardiovascular Pharmacology
Issue numberSUPPL. 2
Publication statusPublished - 1998


  • Combination therapy
  • Hypertension
  • Mechanisms of action
  • Patient compliance

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology


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