Present status and future challenges of electroencephalography- and magnetic resonance imaging-based monitoring in preclinical models of focal cerebral ischemia

Slavianka G. Moyanova, Rick M. Dijkhuizen

Research output: Contribution to journalArticle

Abstract

Animal models are useful tools for better understanding the mechanisms underlying neurological deterioration after an ischemic insult as well as subsequent evolution of changes and recovery of functions. In response to the updated requirements for preclinical investigations of stroke to include relevant functional measurement techniques and biomarker endpoints, we here review the state of knowledge on application of some translational electrophysiological and neuroimaging methods, and in particular, electroencephalography monitoring and magnetic resonance imaging in rodent models of ischemic stroke. This may lead to improvement of diagnostic methods and identification of new therapeutic targets, which would considerably advance the translational value of preclinical stroke research.

Original languageEnglish
Pages (from-to)22-36
Number of pages15
JournalBrain Research Bulletin
Volume102
DOIs
Publication statusPublished - Mar 2014

Fingerprint

Brain Ischemia
Electroencephalography
Stroke
Magnetic Resonance Imaging
Recovery of Function
Neuroimaging
Rodentia
Animal Models
Biomarkers
Research
Therapeutics

Keywords

  • EEG
  • Focal models of stroke
  • MR imaging
  • Rodents

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Present status and future challenges of electroencephalography- and magnetic resonance imaging-based monitoring in preclinical models of focal cerebral ischemia. / Moyanova, Slavianka G.; Dijkhuizen, Rick M.

In: Brain Research Bulletin, Vol. 102, 03.2014, p. 22-36.

Research output: Contribution to journalArticle

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