Abstract
Animal models are useful tools for better understanding the mechanisms underlying neurological deterioration after an ischemic insult as well as subsequent evolution of changes and recovery of functions. In response to the updated requirements for preclinical investigations of stroke to include relevant functional measurement techniques and biomarker endpoints, we here review the state of knowledge on application of some translational electrophysiological and neuroimaging methods, and in particular, electroencephalography monitoring and magnetic resonance imaging in rodent models of ischemic stroke. This may lead to improvement of diagnostic methods and identification of new therapeutic targets, which would considerably advance the translational value of preclinical stroke research.
| Original language | English |
|---|---|
| Pages (from-to) | 22-36 |
| Number of pages | 15 |
| Journal | Brain Research Bulletin |
| Volume | 102 |
| DOIs | |
| Publication status | Published - Mar 2014 |
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Keywords
- EEG
- Focal models of stroke
- MR imaging
- Rodents
ASJC Scopus subject areas
- Neuroscience(all)
- Medicine(all)
Cite this
Present status and future challenges of electroencephalography- and magnetic resonance imaging-based monitoring in preclinical models of focal cerebral ischemia. / Moyanova, Slavianka G.; Dijkhuizen, Rick M.
In: Brain Research Bulletin, Vol. 102, 03.2014, p. 22-36.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Present status and future challenges of electroencephalography- and magnetic resonance imaging-based monitoring in preclinical models of focal cerebral ischemia
AU - Moyanova, Slavianka G.
AU - Dijkhuizen, Rick M.
PY - 2014/3
Y1 - 2014/3
N2 - Animal models are useful tools for better understanding the mechanisms underlying neurological deterioration after an ischemic insult as well as subsequent evolution of changes and recovery of functions. In response to the updated requirements for preclinical investigations of stroke to include relevant functional measurement techniques and biomarker endpoints, we here review the state of knowledge on application of some translational electrophysiological and neuroimaging methods, and in particular, electroencephalography monitoring and magnetic resonance imaging in rodent models of ischemic stroke. This may lead to improvement of diagnostic methods and identification of new therapeutic targets, which would considerably advance the translational value of preclinical stroke research.
AB - Animal models are useful tools for better understanding the mechanisms underlying neurological deterioration after an ischemic insult as well as subsequent evolution of changes and recovery of functions. In response to the updated requirements for preclinical investigations of stroke to include relevant functional measurement techniques and biomarker endpoints, we here review the state of knowledge on application of some translational electrophysiological and neuroimaging methods, and in particular, electroencephalography monitoring and magnetic resonance imaging in rodent models of ischemic stroke. This may lead to improvement of diagnostic methods and identification of new therapeutic targets, which would considerably advance the translational value of preclinical stroke research.
KW - EEG
KW - Focal models of stroke
KW - MR imaging
KW - Rodents
UR - http://www.scopus.com/inward/record.url?scp=84894545946&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84894545946&partnerID=8YFLogxK
U2 - 10.1016/j.brainresbull.2014.01.003
DO - 10.1016/j.brainresbull.2014.01.003
M3 - Article
C2 - 24462642
AN - SCOPUS:84894545946
VL - 102
SP - 22
EP - 36
JO - Brain Research Bulletin
JF - Brain Research Bulletin
SN - 0361-9230
ER -