Beta-bloccanti e sistema cardiovascolare: Attuali acquisizioni e controversie

Translated title of the contribution: Present trends and controversies in the use of beta-blockers in cardiovascular diseases

Roberto Spoladore, Gabriele Fragasso, Claudia Montanaro, Francesco Maranta, Camilla Torlasco, Stefano Gerosa, Alberto Margonato

Research output: Contribution to journalArticlepeer-review

Abstract

In this paper we summarize present trends and controversies in the use of beta-blockers in cardiovascular diseases. Beta-blockers are catecolamine competitive inhibitors and act through alpha and beta adrenergic receptors blockade. Different agents have a dose-dependent affinity for different beta adrenergic receptors (beta 1, beta 2, beta 3) which is less with higher doses. The most important therapeutic effects of beta-blockers are on cardiovascular system, where they act as negative chronotropic and inotropic agents, lowering cardiac work and improving oxygen demand/supply ratio. Clinical indications are numerous. For their anti-ischemic activity beta-blockers are used as anti-anginal drugs and in acute and previous myocardial infarction for preventing total and cardiovascular mortality. Combined use of beta-blockers and ACE inhibitors slows down heart failure progression and reduces cardiovascular mortality. Beta-blockers are useful in treating focal atrial tachycardia and supra ventricular paroxysmal tachycardia, by reducing sinus node automaticity and delay atrio-ventricular conduction; they also prevent sudden cardiac death and ventricular tachycardia associated with increased sympathetic activity. There is no indication in treating primary non-complicated hypertension with beta-blockers as first-line drugs. Different metabolic effects of selective and non-selective beta-blockers are actually debated. In conclusion, betablockers have indication in the treatment of many cardiovascular diseases. Further studies are needed for better understanding the differences in cardiac and peripheral beta-blockers effects depending on their selectivity.

Translated title of the contributionPresent trends and controversies in the use of beta-blockers in cardiovascular diseases
Original languageItalian
Pages (from-to)429-441
Number of pages13
JournalRecenti Progressi in Medicina
Volume101
Issue number11
DOIs
Publication statusPublished - Nov 2010

ASJC Scopus subject areas

  • Medicine(all)

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