Presentation and pattern of symptoms in 382 patients with glanzmann thrombasthenia in Iran

G. Toogeh, R. Sharifian, M. Lak, R. Safaee, A. Artoni, Flora Peyvandi

Research output: Contribution to journalArticlepeer-review

Abstract

Glanzmann thrombasthenia (GT) is a rare autosomal recessive disease characterized by prolonged bleeding time with normal platelet count and morphology. It is caused by the quantitative or qualitative deficiency of the platelet glycoprotein IIb-IIIa. In 382 Iranian patients with GT diagnosed at a single center during the period 1969-2001, consanguinity between parents was 86.6%, in accord with the high frequency of intrafamilial marriages in Iran. Almost all patients had had abnormal mucocutaneous bleeding (epistaxis and gum bleeding); at follow-up, 4/5 of the patients had been transfused at least once to control hemorrhagic episodes. As expected, almost all the patients had a normal platelet count while the leukocyte count was increased in 19.3%. Among women, an unexpected low rate of pregnancies was observed.

Original languageEnglish
Pages (from-to)198-199
Number of pages2
JournalAmerican Journal of Hematology
Volume77
Issue number2
DOIs
Publication statusPublished - Oct 2004

Keywords

  • Consanguineous marriage
  • Genetic consultation
  • Glanzmann thrombasthenia

ASJC Scopus subject areas

  • Hematology

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