Presentation and validation of the multiple sclerosis depression rating scale: A test specifically devised to investigate affective disorders in multiple sclerosis patients

Davide Quaranta, Camillo Marra, Massimiliano Zinno, Agata Katia Patanella, Maria Josè Messina, Chiara Piccininni, Anna Paola Batocchi, Guido Gainotti

Research output: Contribution to journalArticle

Abstract

Accurate diagnosis of depression in patients affected by MS is important, as it may be a cause of reduced quality of life and increased suicide risk. We present a new scale, the Multiple Sclerosis Depression Rating Scale (MSDRS), and assess its diagnostic accuracy in comparison to the Beck Depression Inventory (BDI). A total of 94 MS participants were classified as non-depressed (N=44) or affected by mood disorder associated to MS with depressive manifestations (MSD-MDDM; N=37) or with a major depression-like episode (MSD-MDL; N=13). Each participant underwent a psychiatric interview, MSDRS, and BDI; diagnostic accuracy was evaluated using area under the ROC curve (AROC). The diagnostic accuracy of MSDRS and BDI was comparable when diagnosing both MSD-MDDM and MSD-MDL (AROC respectively 0.8998 and 0.8659); the MSDRS showed higher accuracy for the diagnosis of MSD-MDL (AROC respectively 0.9278 and 0.8314; p=.038). The MSDRS may be a reliable tool for the diagnosis of depression in MS.

Original languageEnglish
Pages (from-to)571-587
Number of pages17
JournalClinical Neuropsychologist
Volume26
Issue number4
DOIs
Publication statusPublished - May 1 2012

Keywords

  • Beck Depression Inventory
  • Depression
  • Multiple sclerosis

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology
  • Medicine(all)

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