Presentation, diagnosis, and outcomes of acute aortic dissection: 17-year trends from the international registry of acute aortic dissection

Linda A. Pape, Mazen Awais, Elise M. Woznicki, Toru Suzuki, Santi Trimarchi, Arturo Evangelista, Truls Myrmel, Magnus Larsen, Kevin M. Harris, Kevin Greason, Marco Di Eusanio, Eduardo Bossone, Daniel G. Montgomery, Kim A. Eagle, Christoph A. Nienaber, Eric M. Isselbacher, Patrick O'Gara

Research output: Contribution to journalArticlepeer-review


Background Diagnosis, treatment, and outcomes of acute aortic dissection (AAS) are changing. Objectives This study examined 17-year trends in the presentation, diagnosis, and hospital outcomes of AAD from the International Registry of Acute Aortic Dissection (IRAD). Methods Data from 4,428 patients enrolled at 28 IRAD centers between December 26, 1995, and February 6, 2013, were analyzed. Patients were divided according to enrollment date into 6 equal groups and by AAD type: A (n = 2,952) or B (n = 1,476). Results There was no change in the presenting complaints of severe or worst-ever pain for type A and type B AAD (93% and 94%, respectively), nor in the incidence of chest pain (83% and 71%, respectively). Use of computed tomography (CT) for diagnosis of type A increased from 46% to 73% (p <0.001). Surgical management for type A increased from 79% to 90% (p <0.001). Endovascular management of type B increased from 7% to 31% (p <0.001). Type A in-hospital mortality decreased significantly (31% to 22%; p <0.001), as surgical mortality (25% to 18%; p = 0.003). There was no significant trend in in-hospital mortality in type B (from 12% to 14%). Conclusions Presenting symptoms and physical findings of AAD have not changed significantly. Use of chest CT increased for type A. More patients in both groups were managed with interventional procedures: surgery in type A and endovascular therapy in type B. A significant decrease in overall in-hospital mortality was seen for type A but not for type B.

Original languageEnglish
Pages (from-to)350-358
Number of pages9
JournalJournal of the American College of Cardiology
Issue number4
Publication statusPublished - Jul 28 2015


  • acute aortic dissection
  • management
  • outcomes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)


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