Abstract
Objective - To evaluate in a prospective study whether patients with polymyalgia rheumatica (PMR) and patients with rheumatoid arthritis (RA) with PMR-like onset show distinctive clinical and laboratory features. Methods - A cohort of 116 consecutive patients with bilateral girdle pain for at least one month and raised erythrocyte sedimentation rate (ESR) was studied and followed up for 12 months. Laboratory tests included determination of ESR, IgM rheumatoid factor, haemoglobin, white blood cell count, platelet count, percentage of CD8 lymphocytes, serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and glutamyltransferase concentrations. Results - At first examination, RA was diagnosed in 22/116 (19%) patients and PMR in 94 (81%) patients. During the follow up period, 19 additional patients developed RA, and the diagnosis of PMR was confirmed in 65 (56%) patients at the end of the study. Of the clinical and laboratory features, only the presence of peripheral synovitis could differentiate patients who will develop RA from those with "true" PMR, but the positive predictive value of this feature was poor. Conclusion - At present, there are no clinical or routine laboratory features allowing early differentiation between PMR and RA with PMR-like onset.
| Original language | English |
|---|---|
| Pages (from-to) | 1021-1024 |
| Number of pages | 4 |
| Journal | Annals of the Rheumatic Diseases |
| Volume | 60 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2001 |
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ASJC Scopus subject areas
- Rheumatology
- Immunology
Cite this
Presenting features of polymyalgia rheumatica (PMR) and rheumatoid arthritis with PMR-like onset : A prospective study. / Caporali, R.; Montecucco, C.; Epis, O.; Bobbio-Pallavicini, F.; Maio, T.; Cimmino, M. A.
In: Annals of the Rheumatic Diseases, Vol. 60, No. 11, 2001, p. 1021-1024.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Presenting features of polymyalgia rheumatica (PMR) and rheumatoid arthritis with PMR-like onset
T2 - A prospective study
AU - Caporali, R.
AU - Montecucco, C.
AU - Epis, O.
AU - Bobbio-Pallavicini, F.
AU - Maio, T.
AU - Cimmino, M. A.
PY - 2001
Y1 - 2001
N2 - Objective - To evaluate in a prospective study whether patients with polymyalgia rheumatica (PMR) and patients with rheumatoid arthritis (RA) with PMR-like onset show distinctive clinical and laboratory features. Methods - A cohort of 116 consecutive patients with bilateral girdle pain for at least one month and raised erythrocyte sedimentation rate (ESR) was studied and followed up for 12 months. Laboratory tests included determination of ESR, IgM rheumatoid factor, haemoglobin, white blood cell count, platelet count, percentage of CD8 lymphocytes, serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and glutamyltransferase concentrations. Results - At first examination, RA was diagnosed in 22/116 (19%) patients and PMR in 94 (81%) patients. During the follow up period, 19 additional patients developed RA, and the diagnosis of PMR was confirmed in 65 (56%) patients at the end of the study. Of the clinical and laboratory features, only the presence of peripheral synovitis could differentiate patients who will develop RA from those with "true" PMR, but the positive predictive value of this feature was poor. Conclusion - At present, there are no clinical or routine laboratory features allowing early differentiation between PMR and RA with PMR-like onset.
AB - Objective - To evaluate in a prospective study whether patients with polymyalgia rheumatica (PMR) and patients with rheumatoid arthritis (RA) with PMR-like onset show distinctive clinical and laboratory features. Methods - A cohort of 116 consecutive patients with bilateral girdle pain for at least one month and raised erythrocyte sedimentation rate (ESR) was studied and followed up for 12 months. Laboratory tests included determination of ESR, IgM rheumatoid factor, haemoglobin, white blood cell count, platelet count, percentage of CD8 lymphocytes, serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and glutamyltransferase concentrations. Results - At first examination, RA was diagnosed in 22/116 (19%) patients and PMR in 94 (81%) patients. During the follow up period, 19 additional patients developed RA, and the diagnosis of PMR was confirmed in 65 (56%) patients at the end of the study. Of the clinical and laboratory features, only the presence of peripheral synovitis could differentiate patients who will develop RA from those with "true" PMR, but the positive predictive value of this feature was poor. Conclusion - At present, there are no clinical or routine laboratory features allowing early differentiation between PMR and RA with PMR-like onset.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034781260&partnerID=8YFLogxK
U2 - 10.1136/ard.60.11.1021
DO - 10.1136/ard.60.11.1021
M3 - Article
C2 - 11602472
AN - SCOPUS:0034781260
VL - 60
SP - 1021
EP - 1024
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
SN - 0003-4967
IS - 11
ER -