Preservation of auditory P300 in the minimal brain damage syndrome of hypothyroid children

S. Medaglini, T. Locatelli, C. Lia, C. Fornara, V. Della Porta, P. Monzoni, G. F. Rondanini, G. Chiumello, G. Comi

Research output: Contribution to journalArticlepeer-review


In congenital hypothyroidism (CH), despite early treatment, some children can develop neurological and intellectual deficits at later ages. We studied auditory P300 maps in 20 CH children of mean age 9.5 years. Global mental quotient (Wisc-R scale) was tested in 17 patients. Six of these patients were detected by a screening program (group A), while 14 patients were diagnosed clinically and further confirmed by measurements of serum T4, T3 and TSH. Six of these 14 patients had neurological and/or intellectual deficits (group B) while 8 had no deficits (group C). Seventeen children matched for age, sex and socioeconomic status, constituted the control group (D). Statistical analysis (Student's two-tailed t-test) revealed no difference among groups for P300 mean latency and amplitude. The Wisc-R score revealed a mild impairment of cognitive functions in 5 subjects; in these subjects P300 was not delayed. These findings suggest that the generators of P300 are not involved in CH even if a corrective effect of early treatment cannot be excluded.

Original languageEnglish
Pages (from-to)224-230
Number of pages7
JournalBrain Dysfunction
Issue number3-4
Publication statusPublished - 1992


  • congenital hypothyroidism
  • ERPs
  • minimal brain damage syndrome
  • P300

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


Dive into the research topics of 'Preservation of auditory P300 in the minimal brain damage syndrome of hypothyroid children'. Together they form a unique fingerprint.

Cite this