Abstract
Frontoparietal cortex is involved in the explicit processing (awareness) of stimuli. Frontoparietal activation has also been found in studies of subliminal stimulus processing. We hypothesized that an impairment of top-down processes, involved in recurrent neuronal message-passing and the generation of long-latency electrophysiological responses, might provide a more reliable correlate of consciousness in severely brain-damaged patients, than frontoparietal responses. We measured effective connectivity during a mismatch negativity paradigm and found that the only significant difference between patients in a vegetative state and controls was an impairment of backward connectivity from frontal to temporal cortices. This result emphasizes the importance of top-down projections in recurrent processing that involve high-order associative cortices for conscious perception.
| Original language | English |
|---|---|
| Pages (from-to) | 858-862 |
| Number of pages | 5 |
| Journal | Science |
| Volume | 332 |
| Issue number | 6031 |
| DOIs | |
| Publication status | Published - May 13 2011 |
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Preserved feedforward but impaired top-down processes in the vegetative state. / Boly, Melanie; Garrido, Marta Isabel; Gosseries, Olivia; Bruno, Marie Aurélie; Boveroux, Pierre; Schnakers, Caroline; Massimini, Marcello; Litvak, Vladimir; Laureys, Steven; Friston, Karl.
In: Science, Vol. 332, No. 6031, 13.05.2011, p. 858-862.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Preserved feedforward but impaired top-down processes in the vegetative state
AU - Boly, Melanie
AU - Garrido, Marta Isabel
AU - Gosseries, Olivia
AU - Bruno, Marie Aurélie
AU - Boveroux, Pierre
AU - Schnakers, Caroline
AU - Massimini, Marcello
AU - Litvak, Vladimir
AU - Laureys, Steven
AU - Friston, Karl
PY - 2011/5/13
Y1 - 2011/5/13
N2 - Frontoparietal cortex is involved in the explicit processing (awareness) of stimuli. Frontoparietal activation has also been found in studies of subliminal stimulus processing. We hypothesized that an impairment of top-down processes, involved in recurrent neuronal message-passing and the generation of long-latency electrophysiological responses, might provide a more reliable correlate of consciousness in severely brain-damaged patients, than frontoparietal responses. We measured effective connectivity during a mismatch negativity paradigm and found that the only significant difference between patients in a vegetative state and controls was an impairment of backward connectivity from frontal to temporal cortices. This result emphasizes the importance of top-down projections in recurrent processing that involve high-order associative cortices for conscious perception.
AB - Frontoparietal cortex is involved in the explicit processing (awareness) of stimuli. Frontoparietal activation has also been found in studies of subliminal stimulus processing. We hypothesized that an impairment of top-down processes, involved in recurrent neuronal message-passing and the generation of long-latency electrophysiological responses, might provide a more reliable correlate of consciousness in severely brain-damaged patients, than frontoparietal responses. We measured effective connectivity during a mismatch negativity paradigm and found that the only significant difference between patients in a vegetative state and controls was an impairment of backward connectivity from frontal to temporal cortices. This result emphasizes the importance of top-down projections in recurrent processing that involve high-order associative cortices for conscious perception.
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UR - http://www.scopus.com/inward/citedby.url?scp=79956053706&partnerID=8YFLogxK
U2 - 10.1126/science.1202043
DO - 10.1126/science.1202043
M3 - Article
C2 - 21566197
AN - SCOPUS:79956053706
VL - 332
SP - 858
EP - 862
JO - Science
JF - Science
SN - 0036-8075
IS - 6031
ER -