Preserved memory in temporal lobe epilepsy patients after surgery for low-grade tumour. A pilot study

A. R. Giovagnoli, M. Casazza, E. Ciceri, G. Avanzini, G. Broggi

Research output: Contribution to journalArticle

Abstract

The objective was to carry out a pilot study exploring memory outcome in patients with temporal lobe epilepsy (TLE) and low-grade tumour. A prospective study using a competence-related memory assessment was carried out in the Laboratory of Neuropsychology, Epilepsy Center and Neurosurgical Department of the "C. Besta" National Neurological Institute in 24 TLE patients undergoing surgical resection for left (n=12) or right (n=12) low-grade tumours and 36 healthy subjects. Patients underwent mesial or lateral temporal lobe lesionectomy. Neuropsychological tests exploring verbal and visual short-term memory, learning, delayed recall and ability to control interference in memory were applied. Before and after surgery, significant verbal impairment was present in left TLE patients compared to controls and right TLE patients, and visual deficits were present in both groups compared to controls. After surgery, there was no significant decrease in mean verbal or visual memory scores related to the operated side. Some memory abilities subserved by the contralateral temporal lobe improved. Postoperative memory scores were related to preoperative scores, side of operation, age and education. In patients with TLE and low-grade tumour, temporal lobe surgery does not necessarily induce memory deficits. Improvement of memory abilities subserved by the unoperated temporal lobe may be expected.

Original languageEnglish
Pages (from-to)251-258
Number of pages8
JournalNeurological Sciences
Volume28
Issue number5
DOIs
Publication statusPublished - Oct 2007

Fingerprint

Temporal Lobe Epilepsy
Temporal Lobe
Aptitude
Neoplasms
Neuropsychology
Neuropsychological Tests
Memory Disorders
Short-Term Memory
Mental Competency
Epilepsy
Healthy Volunteers
Learning
Prospective Studies
Education

Keywords

  • Learning
  • Low-grade tumour
  • Memory
  • Surgery
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Preserved memory in temporal lobe epilepsy patients after surgery for low-grade tumour. A pilot study. / Giovagnoli, A. R.; Casazza, M.; Ciceri, E.; Avanzini, G.; Broggi, G.

In: Neurological Sciences, Vol. 28, No. 5, 10.2007, p. 251-258.

Research output: Contribution to journalArticle

@article{fb16dc18a1cd400e8550a918ab33075c,
title = "Preserved memory in temporal lobe epilepsy patients after surgery for low-grade tumour. A pilot study",
abstract = "The objective was to carry out a pilot study exploring memory outcome in patients with temporal lobe epilepsy (TLE) and low-grade tumour. A prospective study using a competence-related memory assessment was carried out in the Laboratory of Neuropsychology, Epilepsy Center and Neurosurgical Department of the {"}C. Besta{"} National Neurological Institute in 24 TLE patients undergoing surgical resection for left (n=12) or right (n=12) low-grade tumours and 36 healthy subjects. Patients underwent mesial or lateral temporal lobe lesionectomy. Neuropsychological tests exploring verbal and visual short-term memory, learning, delayed recall and ability to control interference in memory were applied. Before and after surgery, significant verbal impairment was present in left TLE patients compared to controls and right TLE patients, and visual deficits were present in both groups compared to controls. After surgery, there was no significant decrease in mean verbal or visual memory scores related to the operated side. Some memory abilities subserved by the contralateral temporal lobe improved. Postoperative memory scores were related to preoperative scores, side of operation, age and education. In patients with TLE and low-grade tumour, temporal lobe surgery does not necessarily induce memory deficits. Improvement of memory abilities subserved by the unoperated temporal lobe may be expected.",
keywords = "Learning, Low-grade tumour, Memory, Surgery, Temporal lobe epilepsy",
author = "Giovagnoli, {A. R.} and M. Casazza and E. Ciceri and G. Avanzini and G. Broggi",
year = "2007",
month = "10",
doi = "10.1007/s10072-007-0831-z",
language = "English",
volume = "28",
pages = "251--258",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer-Verlag Italia s.r.l.",
number = "5",

}

TY - JOUR

T1 - Preserved memory in temporal lobe epilepsy patients after surgery for low-grade tumour. A pilot study

AU - Giovagnoli, A. R.

AU - Casazza, M.

AU - Ciceri, E.

AU - Avanzini, G.

AU - Broggi, G.

PY - 2007/10

Y1 - 2007/10

N2 - The objective was to carry out a pilot study exploring memory outcome in patients with temporal lobe epilepsy (TLE) and low-grade tumour. A prospective study using a competence-related memory assessment was carried out in the Laboratory of Neuropsychology, Epilepsy Center and Neurosurgical Department of the "C. Besta" National Neurological Institute in 24 TLE patients undergoing surgical resection for left (n=12) or right (n=12) low-grade tumours and 36 healthy subjects. Patients underwent mesial or lateral temporal lobe lesionectomy. Neuropsychological tests exploring verbal and visual short-term memory, learning, delayed recall and ability to control interference in memory were applied. Before and after surgery, significant verbal impairment was present in left TLE patients compared to controls and right TLE patients, and visual deficits were present in both groups compared to controls. After surgery, there was no significant decrease in mean verbal or visual memory scores related to the operated side. Some memory abilities subserved by the contralateral temporal lobe improved. Postoperative memory scores were related to preoperative scores, side of operation, age and education. In patients with TLE and low-grade tumour, temporal lobe surgery does not necessarily induce memory deficits. Improvement of memory abilities subserved by the unoperated temporal lobe may be expected.

AB - The objective was to carry out a pilot study exploring memory outcome in patients with temporal lobe epilepsy (TLE) and low-grade tumour. A prospective study using a competence-related memory assessment was carried out in the Laboratory of Neuropsychology, Epilepsy Center and Neurosurgical Department of the "C. Besta" National Neurological Institute in 24 TLE patients undergoing surgical resection for left (n=12) or right (n=12) low-grade tumours and 36 healthy subjects. Patients underwent mesial or lateral temporal lobe lesionectomy. Neuropsychological tests exploring verbal and visual short-term memory, learning, delayed recall and ability to control interference in memory were applied. Before and after surgery, significant verbal impairment was present in left TLE patients compared to controls and right TLE patients, and visual deficits were present in both groups compared to controls. After surgery, there was no significant decrease in mean verbal or visual memory scores related to the operated side. Some memory abilities subserved by the contralateral temporal lobe improved. Postoperative memory scores were related to preoperative scores, side of operation, age and education. In patients with TLE and low-grade tumour, temporal lobe surgery does not necessarily induce memory deficits. Improvement of memory abilities subserved by the unoperated temporal lobe may be expected.

KW - Learning

KW - Low-grade tumour

KW - Memory

KW - Surgery

KW - Temporal lobe epilepsy

UR - http://www.scopus.com/inward/record.url?scp=35848944426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35848944426&partnerID=8YFLogxK

U2 - 10.1007/s10072-007-0831-z

DO - 10.1007/s10072-007-0831-z

M3 - Article

C2 - 17972039

AN - SCOPUS:35848944426

VL - 28

SP - 251

EP - 258

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

IS - 5

ER -