Preserved transcallosal inhibition to transcranial magnetic stimulation in nondemented elderly patients with leukoaraiosis

Giuseppe Lanza, Rita Bella, Salvatore Giuffrida, Mariagiovanna Cantone, Giovanni Pennisi, Concetto Spampinato, Daniela Giordano, Giulia Malaguarnera, Alberto Raggi, Manuela Pennisi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Structural corpus callosum (CC) changes in patients with leukoaraiosis (LA) are significantly associated with cognitive and motor impairment. The aim of this study is to investigate the transcallosal fibers functioning by means of transcranial magnetic stimulation (TMS) in elderly patients with LA. The resting motor threshold (rMT), the motor-evoked potentials (MEPs), and the controlateral (cSP) and ipsilateral silent periods (iSP) were determined using single-pulse TMS in 15 patients and 15 age-matched controls. The neuropsychological profile and the vascular burden at brain magnetic resonance imaging (MRI) were concomitantly explored. Patients reported abnormal scores at tests evaluating executive control functions. No significant difference was found in TMS measures of intra- and intercortical excitability. No CC lesion was evident at MRI. Transcallosal inhibitory mechanisms to TMS seem to be spared in LA patients, a finding which is in line with neuroimaging features and suggests a functional integrity of the CC despite the ischemic interruption of corticosubcortical loops implicated in cognition and behavior. The observed neurophysiological finding differs from that reported in degenerative dementia, even in the preclinical or early stage. In our group of patients, the pure extent of LA is more related to impairment of frontal lobe abilities rather than functional callosal changes.

Original languageEnglish
Article number351680
JournalBioMed Research International
Volume2013
DOIs
Publication statusPublished - 2013

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Leukoaraiosis
Transcranial Magnetic Stimulation
Corpus Callosum
Magnetic resonance
Neuroimaging
Imaging techniques
Executive Function
Bioelectric potentials
Brain
Magnetic Resonance Imaging
Motor Evoked Potentials
Aptitude
Fibers
Frontal Lobe
Cognition
Blood Vessels
Dementia
Inhibition (Psychology)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Preserved transcallosal inhibition to transcranial magnetic stimulation in nondemented elderly patients with leukoaraiosis. / Lanza, Giuseppe; Bella, Rita; Giuffrida, Salvatore; Cantone, Mariagiovanna; Pennisi, Giovanni; Spampinato, Concetto; Giordano, Daniela; Malaguarnera, Giulia; Raggi, Alberto; Pennisi, Manuela.

In: BioMed Research International, Vol. 2013, 351680, 2013.

Research output: Contribution to journalArticle

Lanza, G, Bella, R, Giuffrida, S, Cantone, M, Pennisi, G, Spampinato, C, Giordano, D, Malaguarnera, G, Raggi, A & Pennisi, M 2013, 'Preserved transcallosal inhibition to transcranial magnetic stimulation in nondemented elderly patients with leukoaraiosis', BioMed Research International, vol. 2013, 351680. https://doi.org/10.1155/2013/351680
Lanza, Giuseppe ; Bella, Rita ; Giuffrida, Salvatore ; Cantone, Mariagiovanna ; Pennisi, Giovanni ; Spampinato, Concetto ; Giordano, Daniela ; Malaguarnera, Giulia ; Raggi, Alberto ; Pennisi, Manuela. / Preserved transcallosal inhibition to transcranial magnetic stimulation in nondemented elderly patients with leukoaraiosis. In: BioMed Research International. 2013 ; Vol. 2013.
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