Presidential lecture hypertension and stroke: Opportunities for prevention and prospects for protection

Giuseppe Mancia, Guido Grassi, Gianfranco Parati, Anna Daffonchio

Research output: Contribution to journalArticlepeer-review


Aim: To review the use of plasma norepinephrine to evaluate sympathetic activity in humans, and to discuss the improvement in assessment of human sympathetic activity brought about by the norepinephrine spillover method and by microneurography. Method: Literature survey. Results: These methods have limitations, and an accurate assessment of sympathetic cardiovascular control should not be limited to an investigation of sympathetic nerve firing or norepinephrine secretion but include cardiac and vascular responses. These responses can be assessed by traditional pharmacological means (for example, a reduction in vascular resistance induced by a-adrenergic blockade) or by a variety of approaches aimed at examining sympathetic cardiovascular modulation in a more integrated fashion, such as the recently developed power spectrum analysis of blood pressure and heart rate. Conclusion: The sensitivity and specificity of all these methods is still under investigation, but in almost every case an increase in sympathetic cardiovascular influence has been reported to occur in hypertension, indicating that sympathetic activation has a pathogenic effect on this condition.

Original languageEnglish
Pages (from-to)S13-S19
JournalJournal of Hypertension
Publication statusPublished - 1993


  • Hypertension
  • Microneurography
  • Plasma norepinephrine
  • Power spectrum analysis
  • Sympathetic activity

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine


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