Presynaptic AMPA receptors: More than just ion channels?

Ursula Schenk, Michela Matteoli

Research output: Contribution to journalArticlepeer-review


AMPA receptor ion channels are of paramount importance for postsynaptic excitation. Several reports demonstrate that AMPA receptors are present in the presynaptic compartment and point to a role of these receptors in the modulation of presynaptic function. We discuss here the possibility that not only ion influx through the receptor, but also biochemical cascades, activated by ligand binding and independent from ion flux, might contribute to AMPA mediated presynaptic modulation.

Original languageEnglish
Pages (from-to)257-260
Number of pages4
JournalBiology of the cell / under the auspices of the European Cell Biology Organization
Issue number4
Publication statusPublished - May 2004


  • AMPA receptors
  • Neurotransmitter release
  • Presynapse
  • Signal transduction

ASJC Scopus subject areas

  • Cell Biology

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