Presynaptic AMPA receptors: More than just ion channels?

Ursula Schenk; Michela Matteoli

doi:10.1016/j.biolcel.2004.01.008

Presynaptic AMPA receptors: More than just ion channels?

Ursula Schenk, Michela Matteoli

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

AMPA receptor ion channels are of paramount importance for postsynaptic excitation. Several reports demonstrate that AMPA receptors are present in the presynaptic compartment and point to a role of these receptors in the modulation of presynaptic function. We discuss here the possibility that not only ion influx through the receptor, but also biochemical cascades, activated by ligand binding and independent from ion flux, might contribute to AMPA mediated presynaptic modulation.

Original language	English
Pages (from-to)	257-260
Number of pages	4
Journal	Biology of the cell / under the auspices of the European Cell Biology Organization
Volume	96
Issue number	4
DOIs	https://doi.org/10.1016/j.biolcel.2004.01.008
Publication status	Published - May 2004

Keywords

AMPA receptors
Neurotransmitter release
Presynapse
Signal transduction

ASJC Scopus subject areas

Cell Biology

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10.1016/j.biolcel.2004.01.008

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title = "Presynaptic AMPA receptors: More than just ion channels?",

abstract = "AMPA receptor ion channels are of paramount importance for postsynaptic excitation. Several reports demonstrate that AMPA receptors are present in the presynaptic compartment and point to a role of these receptors in the modulation of presynaptic function. We discuss here the possibility that not only ion influx through the receptor, but also biochemical cascades, activated by ligand binding and independent from ion flux, might contribute to AMPA mediated presynaptic modulation.",

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AU - Matteoli, Michela

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AB - AMPA receptor ion channels are of paramount importance for postsynaptic excitation. Several reports demonstrate that AMPA receptors are present in the presynaptic compartment and point to a role of these receptors in the modulation of presynaptic function. We discuss here the possibility that not only ion influx through the receptor, but also biochemical cascades, activated by ligand binding and independent from ion flux, might contribute to AMPA mediated presynaptic modulation.

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KW - Neurotransmitter release

KW - Presynapse

KW - Signal transduction

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Presynaptic AMPA receptors: More than just ion channels?

Abstract

Keywords

ASJC Scopus subject areas

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