Abstract
We used electron microscopic immunocytochemistry with antibodies against NR1 and NR2A and B subunits to study the distribution of N-methyl-D-aspartate (NMDA) receptors in presynaptic axon terminals in the rat cerebral cortex. In all sections examined, NR1 and NR2A/B immunoreactivities were observed in axon terminals: NR1- and NR2A/B-positive axon terminals made both symmetrical and asymmetrical synapses on unlabelled dendritic profiles. Combined pre- and post-embedding studies showed that all NR1 and NR2A/B-positive axon terminals making symmetrical synapses were γ-aminobutyric acid (GABA)-positive. These observations show that both auto- and hetero-NMDA receptors do exist in the cerebral cortex, and indicate that part of the effects of NMDA receptor activation might be determined by modulating glutamate and GABA release.
| Original language | English |
|---|---|
| Pages (from-to) | 2773-2776 |
| Number of pages | 4 |
| Journal | NeuroReport |
| Volume | 7 |
| Issue number | 15-17 |
| Publication status | Published - 1996 |
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Keywords
- Autoreceptors
- Cerebral cortex
- Glutamate
- Heteroreceptors
- NMDA receptors
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Presynaptic NMDA receptors in the neocortex are both auto- and heteroreceptors. / DeBiasi, Silvia; Minelli, Andrea; Melone, Marcello; Conti, Fiorenzo.
In: NeuroReport, Vol. 7, No. 15-17, 1996, p. 2773-2776.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Presynaptic NMDA receptors in the neocortex are both auto- and heteroreceptors
AU - DeBiasi, Silvia
AU - Minelli, Andrea
AU - Melone, Marcello
AU - Conti, Fiorenzo
PY - 1996
Y1 - 1996
N2 - We used electron microscopic immunocytochemistry with antibodies against NR1 and NR2A and B subunits to study the distribution of N-methyl-D-aspartate (NMDA) receptors in presynaptic axon terminals in the rat cerebral cortex. In all sections examined, NR1 and NR2A/B immunoreactivities were observed in axon terminals: NR1- and NR2A/B-positive axon terminals made both symmetrical and asymmetrical synapses on unlabelled dendritic profiles. Combined pre- and post-embedding studies showed that all NR1 and NR2A/B-positive axon terminals making symmetrical synapses were γ-aminobutyric acid (GABA)-positive. These observations show that both auto- and hetero-NMDA receptors do exist in the cerebral cortex, and indicate that part of the effects of NMDA receptor activation might be determined by modulating glutamate and GABA release.
AB - We used electron microscopic immunocytochemistry with antibodies against NR1 and NR2A and B subunits to study the distribution of N-methyl-D-aspartate (NMDA) receptors in presynaptic axon terminals in the rat cerebral cortex. In all sections examined, NR1 and NR2A/B immunoreactivities were observed in axon terminals: NR1- and NR2A/B-positive axon terminals made both symmetrical and asymmetrical synapses on unlabelled dendritic profiles. Combined pre- and post-embedding studies showed that all NR1 and NR2A/B-positive axon terminals making symmetrical synapses were γ-aminobutyric acid (GABA)-positive. These observations show that both auto- and hetero-NMDA receptors do exist in the cerebral cortex, and indicate that part of the effects of NMDA receptor activation might be determined by modulating glutamate and GABA release.
KW - Autoreceptors
KW - Cerebral cortex
KW - Glutamate
KW - Heteroreceptors
KW - NMDA receptors
UR - http://www.scopus.com/inward/record.url?scp=0029851909&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029851909&partnerID=8YFLogxK
M3 - Article
C2 - 8981465
AN - SCOPUS:0029851909
VL - 7
SP - 2773
EP - 2776
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 15-17
ER -