Presynaptic release-regulating NMDA receptors in isolated nerve terminals: A narrative review

Research output: Contribution to journalReview articlepeer-review

Abstract

The existence of presynaptic, release-regulating NMDA receptors in the CNS has been long matter of discussion. Most of the reviews dedicated to support this conclusion have preferentially focussed on the results from electrophysiological studies, paying little or no attention to the data obtained with purified synaptosomes, even though this experimental approach has been recognized as providing reliable information concerning the presence and the role of presynaptic release-regulating receptors in the CNS. To fill the gap, this review is dedicated to summarising the results from studies with synaptosomes published during the last 40 years, which support the existence of auto and hetero NMDA receptors controlling the release of transmitters such as glutamate, GABA, dopamine, noradrenaline, 5-HT, acetylcholine and peptides, in the CNS of mammals. The review also deals with the results from immunochemical studies in isolated nerve endings that confirm the functional observations.

Original languageEnglish
Pages (from-to)1001-1017
Number of pages17
JournalBritish Journal of Pharmacology
Volume178
Issue number5
DOIs
Publication statusPublished - Mar 2021

Keywords

  • GluN subunit
  • glutamate
  • glycine
  • presynaptic NMDA receptor
  • synaptosomes
  • transmitter release

ASJC Scopus subject areas

  • Pharmacology

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