Preterm cord blood contains a higher proportion of immature hematopoietic progenitors compared to term samples

Marina Podestà; Matteo Bruschettini; Claudia Cossu; Federica Sabatini; Monica Dagnino; Olga Romantsik; Grazia Maria Spaggiari; Luca Antonio Ramenghi; Francesco Frassoni

doi:10.1371/journal.pone.0138680

Preterm cord blood contains a higher proportion of immature hematopoietic progenitors compared to term samples

Marina Podestà, Matteo Bruschettini, Claudia Cossu, Federica Sabatini, Monica Dagnino, Olga Romantsik, Grazia Maria Spaggiari, Luca Antonio Ramenghi, Francesco Frassoni

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Cord blood contains high number of hematopoietic cells that after birth disappear. In this paper we have studied the functional properties of the umbilical cord blood progenitor cells collected from term and preterm neonates to establish whether quantitative and/or qualitative differences exist between the two groups. Methods and Results: Our results indicate that the percentage of total CD34+ cells was significantly higher in preterm infants compared to full term: 0.61% (range 0.15-4.8) vs 0.3% (0.032-2.23) p = 0.0001 and in neonates 32 wks GA: 0.95% (range 0.18-4.8) and 0.36% (0.15-3.2) respectively p = 0.0025. The majority of CD34+ cells co-expressed CD71 antigen (p

Original language	English
Article number	e0138680
Journal	PLoS One
Volume	10
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0138680
Publication status	Published - Sep 29 2015

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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Preterm cord blood contains a higher proportion of immature hematopoietic progenitors compared to term samples. / Podestà, Marina; Bruschettini, Matteo; Cossu, Claudia; Sabatini, Federica; Dagnino, Monica; Romantsik, Olga; Spaggiari, Grazia Maria; Ramenghi, Luca Antonio; Frassoni, Francesco.

In: PLoS One, Vol. 10, No. 9, e0138680, 29.09.2015.

Research output: Contribution to journal › Article › peer-review

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AU - Podestà, Marina

AU - Bruschettini, Matteo

AU - Cossu, Claudia

AU - Sabatini, Federica

AU - Dagnino, Monica

AU - Romantsik, Olga

AU - Spaggiari, Grazia Maria

AU - Ramenghi, Luca Antonio

AU - Frassoni, Francesco

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Preterm cord blood contains a higher proportion of immature hematopoietic progenitors compared to term samples

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