TY - JOUR
T1 - Preterm cord blood contains a higher proportion of immature hematopoietic progenitors compared to term samples
AU - Podestà, Marina
AU - Bruschettini, Matteo
AU - Cossu, Claudia
AU - Sabatini, Federica
AU - Dagnino, Monica
AU - Romantsik, Olga
AU - Spaggiari, Grazia Maria
AU - Ramenghi, Luca Antonio
AU - Frassoni, Francesco
PY - 2015/9/29
Y1 - 2015/9/29
N2 - Background: Cord blood contains high number of hematopoietic cells that after birth disappear. In this paper we have studied the functional properties of the umbilical cord blood progenitor cells collected from term and preterm neonates to establish whether quantitative and/or qualitative differences exist between the two groups. Methods and Results: Our results indicate that the percentage of total CD34+ cells was significantly higher in preterm infants compared to full term: 0.61% (range 0.15-4.8) vs 0.3% (0.032-2.23) p = 0.0001 and in neonates 32 wks GA: 0.95% (range 0.18-4.8) and 0.36% (0.15-3.2) respectively p = 0.0025. The majority of CD34+ cells co-expressed CD71 antigen (p
AB - Background: Cord blood contains high number of hematopoietic cells that after birth disappear. In this paper we have studied the functional properties of the umbilical cord blood progenitor cells collected from term and preterm neonates to establish whether quantitative and/or qualitative differences exist between the two groups. Methods and Results: Our results indicate that the percentage of total CD34+ cells was significantly higher in preterm infants compared to full term: 0.61% (range 0.15-4.8) vs 0.3% (0.032-2.23) p = 0.0001 and in neonates 32 wks GA: 0.95% (range 0.18-4.8) and 0.36% (0.15-3.2) respectively p = 0.0025. The majority of CD34+ cells co-expressed CD71 antigen (p
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U2 - 10.1371/journal.pone.0138680
DO - 10.1371/journal.pone.0138680
M3 - Article
AN - SCOPUS:84947997830
VL - 10
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 9
M1 - e0138680
ER -