Preterm cord blood contains a higher proportion of immature hematopoietic progenitors compared to term samples

Marina Podestà, Matteo Bruschettini, Claudia Cossu, Federica Sabatini, Monica Dagnino, Olga Romantsik, Grazia Maria Spaggiari, Luca Antonio Ramenghi, Francesco Frassoni

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Cord blood contains high number of hematopoietic cells that after birth disappear. In this paper we have studied the functional properties of the umbilical cord blood progenitor cells collected from term and preterm neonates to establish whether quantitative and/or qualitative differences exist between the two groups. Methods and Results: Our results indicate that the percentage of total CD34+ cells was significantly higher in preterm infants compared to full term: 0.61% (range 0.15-4.8) vs 0.3% (0.032-2.23) p = 0.0001 and in neonates 32 wks GA: 0.95% (range 0.18-4.8) and 0.36% (0.15-3.2) respectively p = 0.0025. The majority of CD34+ cells co-expressed CD71 antigen (p

Original languageEnglish
Article numbere0138680
JournalPLoS One
Volume10
Issue number9
DOIs
Publication statusPublished - Sep 29 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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